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NEDD4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes

Author

Listed:
  • Zhi Zhou

    (Genetic Strains Research Center, National Institute of Genetics
    School of Life Science and Technology, ShanghaiTech University)

  • Hiroshi Kawabe

    (Max Planck Institute of Experimental Medicine)

  • Atsushi Suzuki

    (Faculty of Engineering, Yokohama National University)

  • Kaori Shinmyozu

    (National Cerebral and Cardiovascular Center)

  • Yumiko Saga

    (Genetic Strains Research Center, National Institute of Genetics
    SOKENDAI
    Graduate School of Science, The University of Tokyo)

Abstract

P bodies (PBs) and stress granules (SGs) are conserved cytoplasmic aggregates of cellular messenger ribonucleoprotein complexes (mRNPs) that are implicated in mRNA metabolism and play crucial roles in adult stem cell homeostasis and stress responses. However, the mechanisms underlying the dynamics of mRNP granules are poorly understood. Here, we report NEDD4, an E3 ubiquitin ligase, as a key regulator of mRNP dynamics that controls the size of the spermatogonial progenitor cell (SPC) pool. We find that NEDD4 targets an RNA-binding protein, NANOS2, in spermatogonia to destabilize it, leading to cell differentiation. In addition, NEDD4 is required for SG clearance. NEDD4 targets SGs and facilitates their rapid clearance through the endosomal–lysosomal pathway during the recovery period. Therefore, NEDD4 controls the turnover of mRNP components and inhibits pathological SG accumulation. Accordingly, we propose that a NEDD4-mediated mechanism regulates mRNP dynamics, and facilitates SPC homeostasis and viability under normal and stress conditions.

Suggested Citation

  • Zhi Zhou & Hiroshi Kawabe & Atsushi Suzuki & Kaori Shinmyozu & Yumiko Saga, 2017. "NEDD4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes," Nature Communications, Nature, vol. 8(1), pages 1-13, August.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15662
    DOI: 10.1038/ncomms15662
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