IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v8y2017i1d10.1038_ncomms15627.html
   My bibliography  Save this article

Expression of CD226 is associated to but not required for NK cell education

Author

Listed:
  • Arnika K. Wagner

    (Tumor and Cell Biology, Karolinska Institutet
    Center for Hematology and Regenerative Medicine, Karolinska Institutet)

  • Nadir Kadri

    (Center for Hematology and Regenerative Medicine, Karolinska Institutet)

  • Johanna Snäll

    (Center for Infectious Medicine, Karolinska Institutet, F59)

  • Petter Brodin

    (Science for Life Laboratory, Karolinska Institutet, and Unit of Infectious Diseases, Karolinska University Hospital
    Karolinska University Hospital)

  • Susan Gilfillan

    (Campus Box 8118, Washington University School of Medicine)

  • Marco Colonna

    (Campus Box 8118, Washington University School of Medicine)

  • Günter Bernhardt

    (Institute of Immunology, Building 11, Hannover Medical School)

  • Petter Höglund

    (Center for Hematology and Regenerative Medicine, Karolinska Institutet)

  • Klas Kärre

    (Tumor and Cell Biology, Karolinska Institutet)

  • Benedict J. Chambers

    (Center for Infectious Medicine, Karolinska Institutet, F59)

Abstract

DNAX accessory molecule-1 (DNAM-1, also known as CD226) is an activating receptor expressed on subsets of natural killer (NK) and T cells, interacts with its ligands CD155 or CD112, and has co-varied expression with inhibitory receptors. Since inhibitory receptors control NK-cell activation and are necessary for MHC-I-dependent education, we investigated whether DNAM-1 expression is also involved in NK-cell education. Here we show an MHC-I-dependent correlation between DNAM-1 expression and NK-cell education, and an association between DNAM-1 and NKG2A that occurs even in MHC class I deficient mice. DNAM-1 is expressed early during NK-cell development, precedes the expression of MHC-I-specific inhibitory receptors, and is modulated in an education-dependent fashion. Cd226−/− mice have missing self-responses and NK cells with a normal receptor repertoire. We propose a model in which NK-cell education prevents or delays downregulation of DNAM-1. This molecule endows educated NK cells with enhanced effector functions but is dispensable for education.

Suggested Citation

  • Arnika K. Wagner & Nadir Kadri & Johanna Snäll & Petter Brodin & Susan Gilfillan & Marco Colonna & Günter Bernhardt & Petter Höglund & Klas Kärre & Benedict J. Chambers, 2017. "Expression of CD226 is associated to but not required for NK cell education," Nature Communications, Nature, vol. 8(1), pages 1-14, August.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15627
    DOI: 10.1038/ncomms15627
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms15627
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms15627?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15627. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.