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Mir-132/212 is required for maturation of binocular matching of orientation preference and depth perception

Author

Listed:
  • Raffaele Mazziotti

    (Psychology, Drug Research and Child Health NEUROFARBA University of Florence)

  • Laura Baroncelli

    (Institute of Neuroscience, National Research Council, Via Moruzzi)

  • Nicholas Ceglia

    (University of California, Irvine
    Institute for Genomics and Bioinformatics, University of California, Irvine)

  • Gabriele Chelini

    (Psychology, Drug Research and Child Health NEUROFARBA University of Florence)

  • Grazia Della Sala

    (Psychology, Drug Research and Child Health NEUROFARBA University of Florence)

  • Christophe Magnan

    (University of California, Irvine
    Institute for Genomics and Bioinformatics, University of California, Irvine)

  • Debora Napoli

    (BIO@SNS lab, Scuola Normale Superiore via Moruzzi)

  • Elena Putignano

    (Institute of Neuroscience, National Research Council, Via Moruzzi)

  • Davide Silingardi

    (Psychology, Drug Research and Child Health NEUROFARBA University of Florence)

  • Jonida Tola

    (Institute of Neuroscience, National Research Council, Via Moruzzi)

  • Paola Tognini

    (BIO@SNS lab, Scuola Normale Superiore via Moruzzi
    University of California, Irvine
    Center for Epigenetics and Metabolism, University of California, Irvine)

  • J. Simon C. Arthur

    (School of Life Sciences, University of Dundee)

  • Pierre Baldi

    (University of California, Irvine
    Institute for Genomics and Bioinformatics, University of California, Irvine
    University of California, Irvine
    Center for Epigenetics and Metabolism, University of California, Irvine)

  • Tommaso Pizzorusso

    (Psychology, Drug Research and Child Health NEUROFARBA University of Florence
    Institute of Neuroscience, National Research Council, Via Moruzzi
    BIO@SNS lab, Scuola Normale Superiore via Moruzzi)

Abstract

MicroRNAs (miRNAs) are known to mediate post-transcriptional gene regulation, but their role in postnatal brain development is still poorly explored. We show that the expression of many miRNAs is dramatically regulated during functional maturation of the mouse visual cortex with miR-132/212 family being one of the top upregulated miRNAs. Age-downregulated transcripts are significantly enriched in miR-132/miR-212 putative targets and in genes upregulated in miR-132/212 null mice. At a functional level, miR-132/212 deletion affects development of receptive fields of cortical neurons determining a specific impairment of binocular matching of orientation preference, but leaving orientation and direction selectivity unaltered. This deficit is associated with reduced depth perception in the visual cliff test. Deletion of miR-132/212 from forebrain excitatory neurons replicates the binocular matching deficits. Thus, miR-132/212 family shapes the age-dependent transcriptome of the visual cortex during a specific developmental window resulting in maturation of binocular cortical cells and depth perception.

Suggested Citation

  • Raffaele Mazziotti & Laura Baroncelli & Nicholas Ceglia & Gabriele Chelini & Grazia Della Sala & Christophe Magnan & Debora Napoli & Elena Putignano & Davide Silingardi & Jonida Tola & Paola Tognini &, 2017. "Mir-132/212 is required for maturation of binocular matching of orientation preference and depth perception," Nature Communications, Nature, vol. 8(1), pages 1-12, August.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15488
    DOI: 10.1038/ncomms15488
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