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Prevalence of sexual dimorphism in mammalian phenotypic traits

Author

Listed:
  • Natasha A. Karp

    (Mouse Informatics Group, The Wellcome Trust Sanger Institute
    Quantitative Biology, AstraZeneca)

  • Jeremy Mason

    (European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Trust Genome Campus)

  • Arthur L. Beaudet

    (Human and Molecular Genetics, Baylor College of Medicine)

  • Yoav Benjamini

    (Tel Aviv University)

  • Lynette Bower

    (Mouse Biology Program, University of California)

  • Robert E. Braun

    (The Jackson Laboratory)

  • Steve D.M. Brown

    (MRC Harwell Institute, Harwell Campus)

  • Elissa J. Chesler

    (The Jackson Laboratory)

  • Mary E. Dickinson

    (Molecular Physiology and Biophysics, Baylor College of Medicine)

  • Ann M. Flenniken

    (The Centre for Phenogenomics)

  • Helmut Fuchs

    (German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München)

  • Martin Hrabe de Angelis

    (German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München
    School of Life Science Weihenstephan, Technische Universität München
    German Center for Diabetes Research (DZD))

  • Xiang Gao

    (Model Animal Research Center, Nanjing University)

  • Shiying Guo

    (Model Animal Research Center, Nanjing University)

  • Simon Greenaway

    (MRC Harwell Institute, Harwell Campus)

  • Ruth Heller

    (Tel Aviv University)

  • Yann Herault

    (CELPHEDIA, PHENOMIN, Institut Clinique de la Souris
    Institut de Génétique et de Biologie Moléculaire et Cellulaire
    Centre National de la Recherche Scientifique
    Institut National de la Santé et de la Recherche Médicale)

  • Monica J. Justice

    (The Hospital for Sick Children)

  • Natalja Kurbatova

    (Tel Aviv University)

  • Christopher J. Lelliott

    (Mouse Genetics Project, The Wellcome Trust Sanger Institute)

  • K.C. Kent Lloyd

    (Mouse Biology Program, University of California)

  • Ann-Marie Mallon

    (MRC Harwell Institute, Harwell Campus)

  • Judith E. Mank

    (Evolution & Environment, University College London)

  • Hiroshi Masuya

    (BioResource Center, RIKEN)

  • Colin McKerlie

    (The Centre for Phenogenomics
    The Hospital for Sick Children)

  • Terrence F. Meehan

    (European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Trust Genome Campus)

  • Richard F. Mott

    (Genetics Institute, University College London)

  • Stephen A. Murray

    (The Jackson Laboratory)

  • Helen Parkinson

    (European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Trust Genome Campus)

  • Ramiro Ramirez-Solis

    (Mouse Genetics Project, The Wellcome Trust Sanger Institute)

  • Luis Santos

    (MRC Harwell Institute, Harwell Campus)

  • John R. Seavitt

    (Human and Molecular Genetics, Baylor College of Medicine)

  • Damian Smedley

    (Clinical Pharmacology, Queen Mary University of London)

  • Tania Sorg

    (CELPHEDIA, PHENOMIN, Institut Clinique de la Souris
    Institut de Génétique et de Biologie Moléculaire et Cellulaire
    Centre National de la Recherche Scientifique
    Institut National de la Santé et de la Recherche Médicale)

  • Anneliese O. Speak

    (Mouse Genetics Project, The Wellcome Trust Sanger Institute)

  • Karen P. Steel

    (Mouse Genetics Project, The Wellcome Trust Sanger Institute
    Wolfson Centre for Age-Related Diseases, King's College London)

  • Karen L. Svenson

    (The Jackson Laboratory)

  • Shigeharu Wakana

    (BioResource Center, RIKEN)

  • David West

    (Children’s Hospital Oakland Research Institute)

  • Sara Wells

    (MRC Harwell Institute, Harwell Campus)

  • Henrik Westerberg

    (MRC Harwell Institute, Harwell Campus)

  • Shay Yaacoby

    (Tel Aviv University)

  • Jacqueline K. White

    (The Jackson Laboratory
    Mouse Genetics Project, The Wellcome Trust Sanger Institute)

Abstract

The role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorphic effects in some biological studies. Here, we used high-throughput phenotype data from 14,250 wildtype and 40,192 mutant mice (representing 2,186 knockout lines), analysed for up to 234 traits, and found a large proportion of mammalian traits both in wildtype and mutants are influenced by sex. This result has implications for interpreting disease phenotypes in animal models and humans.

Suggested Citation

  • Natasha A. Karp & Jeremy Mason & Arthur L. Beaudet & Yoav Benjamini & Lynette Bower & Robert E. Braun & Steve D.M. Brown & Elissa J. Chesler & Mary E. Dickinson & Ann M. Flenniken & Helmut Fuchs & Mar, 2017. "Prevalence of sexual dimorphism in mammalian phenotypic traits," Nature Communications, Nature, vol. 8(1), pages 1-12, August.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15475
    DOI: 10.1038/ncomms15475
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    Cited by:

    1. Laura A. B. Wilson & Susanne R. K. Zajitschek & Malgorzata Lagisz & Jeremy Mason & Hamed Haselimashhadi & Shinichi Nakagawa, 2022. "Sex differences in allometry for phenotypic traits in mice indicate that females are not scaled males," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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