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Ccl2/Ccr2 signalling recruits a distinct fetal microchimeric population that rescues delayed maternal wound healing

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  • Mathieu Castela

    (INSERM UMRS_938, Saint-Antoine Research Center
    UPMC Université Paris 6,)

  • Dany Nassar

    (Université Paris 5 Descartes
    American University of Beirut, Riad EI Soph)

  • Maria Sbeih

    (INSERM UMRS_938, Saint-Antoine Research Center
    UPMC Université Paris 6,)

  • Marie Jachiet

    (INSERM UMRS_938, Saint-Antoine Research Center
    UPMC Université Paris 6,
    Université Paris 5 Descartes)

  • Zhe Wang

    (INSERM UMRS_938, Saint-Antoine Research Center)

  • Selim Aractingi

    (INSERM UMRS_938, Saint-Antoine Research Center
    Université Paris 5 Descartes
    Hôpital Cochin, AP-HP)

Abstract

Foetal microchimeric cells (FMCs) traffic into maternal circulation during pregnancy and persist for decades after delivery. Upon maternal injury, FMCs migrate to affected sites where they participate in tissue healing. However, the specific signals regulating the trafficking of FMCs to injury sites had to be identified. Here we report that, in mice, a subset of FMCs implicated in tissue repair displays CD11b+ CD34+ CD31+ phenotype and highly express C-C chemokine receptor 2 (Ccr2). The Ccr2 ligand chemokine ligand 2 (Ccl2) enhances the recruitment of FMCs to maternal wounds where these cells transdifferentiate into endothelial cells and stimulate angiogenesis through Cxcl1 secretion. Ccl2 administration improves delayed maternal wound healing in pregnant and postpartum mice but never in virgin ones. This role of Ccl2/Ccr2 signalling opens new strategies for tissue repair through natural stem cell therapy, a concept that can be later applied to other types of maternal diseases.

Suggested Citation

  • Mathieu Castela & Dany Nassar & Maria Sbeih & Marie Jachiet & Zhe Wang & Selim Aractingi, 2017. "Ccl2/Ccr2 signalling recruits a distinct fetal microchimeric population that rescues delayed maternal wound healing," Nature Communications, Nature, vol. 8(1), pages 1-13, August.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15463
    DOI: 10.1038/ncomms15463
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