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Light-driven liquid metal nanotransformers for biomedical theranostics

Author

Listed:
  • Svetlana A. Chechetka

    (Nanomaterials Research Institute (NMRI), National Institute of Advanced Industrial Science and Technology (AIST))

  • Yue Yu

    (Nanomaterials Research Institute (NMRI), National Institute of Advanced Industrial Science and Technology (AIST))

  • Xu Zhen

    (School of Chemical and Biomedical Engineering, Nanyang Technological University (NTU))

  • Manojit Pramanik

    (School of Chemical and Biomedical Engineering, Nanyang Technological University (NTU))

  • Kanyi Pu

    (School of Chemical and Biomedical Engineering, Nanyang Technological University (NTU))

  • Eijiro Miyako

    (Nanomaterials Research Institute (NMRI), National Institute of Advanced Industrial Science and Technology (AIST))

Abstract

Room temperature liquid metals (LMs) represent a class of emerging multifunctional materials with attractive novel properties. Here, we show that photopolymerized LMs present a unique nanoscale capsule structure characterized by high water dispersibility and low toxicity. We also demonstrate that the LM nanocapsule generates heat and reactive oxygen species under biologically neutral near-infrared (NIR) laser irradiation. Concomitantly, NIR laser exposure induces a transformation in LM shape, destruction of the nanocapsules, contactless controlled release of the loaded drugs, optical manipulations of a microfluidic blood vessel model and spatiotemporal targeted marking for X-ray-enhanced imaging in biological organs and a living mouse. By exploiting the physicochemical properties of LMs, we achieve effective cancer cell elimination and control of intercellular calcium ion flux. In addition, LMs display a photoacoustic effect in living animals during NIR laser treatment, making this system a powerful tool for bioimaging.

Suggested Citation

  • Svetlana A. Chechetka & Yue Yu & Xu Zhen & Manojit Pramanik & Kanyi Pu & Eijiro Miyako, 2017. "Light-driven liquid metal nanotransformers for biomedical theranostics," Nature Communications, Nature, vol. 8(1), pages 1-19, August.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15432
    DOI: 10.1038/ncomms15432
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    Cited by:

    1. Matthew Wei Ming Tan & Hyunwoo Bark & Gurunathan Thangavel & Xuefei Gong & Pooi See Lee, 2022. "Photothermal modulated dielectric elastomer actuator for resilient soft robots," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. FuYao Sun & LongFei Liu & Tong Liu & XueBin Wang & Qi Qi & ZuSheng Hang & Kai Chen & JianHua Xu & JiaJun Fu, 2023. "Vascular smooth muscle-inspired architecture enables soft yet tough self-healing materials for durable capacitive strain-sensor," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    3. Yingyue Zhang & Hanrui Zhu & Shun An & Wenkui Xing & Benwei Fu & Peng Tao & Wen Shang & Jianbo Wu & Michael D. Dickey & Chengyi Song & Tao Deng, 2024. "Chameleon-inspired tunable multi-layered infrared-modulating system via stretchable liquid metal microdroplets in elastomer film," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    4. Jicheng Niu & Wenjing Liu & Jasmine Xinze Li & Xianglong Pang & Yulin Liu & Chao Zhang & Keyang Yue & Yulin Zhou & Feng Xu & Xiaoguang Li & Fei Li, 2023. "Machining water through laser cutting of nanoparticle-encased water pancakes," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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