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Extra-embryonic tissue spreading directs early embryo morphogenesis in killifish

Author

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  • Germán Reig

    (Anatomy and Developmental Biology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile
    Biomedical Neuroscience Institute, Independencia 1027)

  • Mauricio Cerda

    (Anatomy and Developmental Biology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile
    Biomedical Neuroscience Institute, Independencia 1027)

  • Néstor Sepúlveda

    (Faculty of Physical and Mathematical Sciences, Universidad de Chile)

  • Daniela Flores

    (Anatomy and Developmental Biology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile
    Biomedical Neuroscience Institute, Independencia 1027)

  • Victor Castañeda

    (Anatomy and Developmental Biology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile
    Biomedical Neuroscience Institute, Independencia 1027)

  • Masazumi Tada

    (University College London)

  • Steffen Härtel

    (Anatomy and Developmental Biology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile
    Biomedical Neuroscience Institute, Independencia 1027
    National Center for Health Information Systems CENS)

  • Miguel L. Concha

    (Anatomy and Developmental Biology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile
    Biomedical Neuroscience Institute, Independencia 1027
    Center for Geroscience, Brain Health and Metabolism)

Abstract

The spreading of mesenchymal-like cell layers is critical for embryo morphogenesis and tissue repair, yet we know little of this process in vivo. Here we take advantage of unique developmental features of the non-conventional annual killifish embryo to study the principles underlying tissue spreading in a simple cellular environment, devoid of patterning signals and major morphogenetic cell movements. Using in vivo experimentation and physical modelling we reveal that the extra-embryonic epithelial enveloping cell layer, thought mainly to provide protection to the embryo, directs cell migration and the spreading of embryonic tissue during early development. This function relies on the ability of embryonic cells to couple their autonomous random motility to non-autonomous signals arising from the expansion of the extra-embryonic epithelium, mediated by cell membrane adhesion and tension. Thus, we present a mechanism of extra-embryonic control of embryo morphogenesis that couples the mechanical properties of adjacent tissues in the early killifish embryo.

Suggested Citation

  • Germán Reig & Mauricio Cerda & Néstor Sepúlveda & Daniela Flores & Victor Castañeda & Masazumi Tada & Steffen Härtel & Miguel L. Concha, 2017. "Extra-embryonic tissue spreading directs early embryo morphogenesis in killifish," Nature Communications, Nature, vol. 8(1), pages 1-14, August.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15431
    DOI: 10.1038/ncomms15431
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