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Modeling the process of human tumorigenesis

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  • Sneha Balani

    (Terry Fox Laboratory, British Columbia Cancer Agency)

  • Long V. Nguyen

    (Terry Fox Laboratory, British Columbia Cancer Agency)

  • Connie J. Eaves

    (Terry Fox Laboratory, British Columbia Cancer Agency)

Abstract

Modelling the genesis of human cancers is at a scientific turning point. Starting from primary sources of normal human cells, it is now possible to reproducibly generate several types of malignant cell populations. Powerful methods for clonally tracking and manipulating their appearance and progression in serially transplanted immunodeficient mice are also in place. These developments circumvent historic drawbacks inherent in analyses of cancers produced in model organisms, established human malignant cell lines, or highly heterogeneous patient samples. In this review, we survey the advantages, contributions and limitations of current de novo human tumorigenesis strategies and note several exciting prospects on the horizon.

Suggested Citation

  • Sneha Balani & Long V. Nguyen & Connie J. Eaves, 2017. "Modeling the process of human tumorigenesis," Nature Communications, Nature, vol. 8(1), pages 1-10, August.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15422
    DOI: 10.1038/ncomms15422
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    Cited by:

    1. Syamantak Khan & June Ho Shin & Valentina Ferri & Ning Cheng & Julia E. Noel & Calvin Kuo & John B. Sunwoo & Guillem Pratx, 2021. "High-resolution positron emission microscopy of patient-derived tumor organoids," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    2. Yukinari Haraoka & Yuki Akieda & Yuri Nagai & Chihiro Mogi & Tohru Ishitani, 2022. "Zebrafish imaging reveals TP53 mutation switching oncogene-induced senescence from suppressor to driver in primary tumorigenesis," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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