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Engaging and disengaging recurrent inhibition coincides with sensing and unsensing of a sensory stimulus

Author

Listed:
  • Debajit Saha

    (Washington University in St. Louis)

  • Wensheng Sun

    (Washington University in St. Louis)

  • Chao Li

    (Washington University in St. Louis)

  • Srinath Nizampatnam

    (Washington University in St. Louis)

  • William Padovano

    (Washington University in St. Louis)

  • Zhengdao Chen

    (Washington University in St. Louis)

  • Alex Chen

    (Washington University in St. Louis)

  • Ege Altan

    (Washington University in St. Louis)

  • Ray Lo

    (Washington University in St. Louis)

  • Dennis L. Barbour

    (Washington University in St. Louis)

  • Baranidharan Raman

    (Washington University in St. Louis)

Abstract

Even simple sensory stimuli evoke neural responses that are dynamic and complex. Are the temporally patterned neural activities important for controlling the behavioral output? Here, we investigated this issue. Our results reveal that in the insect antennal lobe, due to circuit interactions, distinct neural ensembles are activated during and immediately following the termination of every odorant. Such non-overlapping response patterns are not observed even when the stimulus intensity or identities were changed. In addition, we find that ON and OFF ensemble neural activities differ in their ability to recruit recurrent inhibition, entrain field-potential oscillations and more importantly in their relevance to behaviour (initiate versus reset conditioned responses). Notably, we find that a strikingly similar strategy is also used for encoding sound onsets and offsets in the marmoset auditory cortex. In sum, our results suggest a general approach where recurrent inhibition is associated with stimulus ‘recognition’ and ‘derecognition’.

Suggested Citation

  • Debajit Saha & Wensheng Sun & Chao Li & Srinath Nizampatnam & William Padovano & Zhengdao Chen & Alex Chen & Ege Altan & Ray Lo & Dennis L. Barbour & Baranidharan Raman, 2017. "Engaging and disengaging recurrent inhibition coincides with sensing and unsensing of a sensory stimulus," Nature Communications, Nature, vol. 8(1), pages 1-19, August.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15413
    DOI: 10.1038/ncomms15413
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    Cited by:

    1. Rishabh Chandak & Baranidharan Raman, 2023. "Neural manifolds for odor-driven innate and acquired appetitive preferences," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    2. Keitaro Obara & Teppei Ebina & Shin-Ichiro Terada & Takanori Uka & Misako Komatsu & Masafumi Takaji & Akiya Watakabe & Kenta Kobayashi & Yoshito Masamizu & Hiroaki Mizukami & Tetsuo Yamamori & Kiyoto , 2023. "Change detection in the primate auditory cortex through feedback of prediction error signals," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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