IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v8y2017i1d10.1038_ncomms15353.html
   My bibliography  Save this article

Genetic architecture of epigenetic and neuronal ageing rates in human brain regions

Author

Listed:
  • Ake T. Lu

    (David Geffen School of Medicine, University of California Los Angeles)

  • Eilis Hannon

    (University of Exeter Medical School, University of Exeter, RILD Building, Barrack Road)

  • Morgan E. Levine

    (David Geffen School of Medicine, University of California Los Angeles
    Center for Neurobehavioral Genetics, University of California Los Angeles)

  • Eileen M. Crimmins

    (Davis School of Gerontology, University of Southern California, Ethel Percy Andrus Gerontology Center)

  • Katie Lunnon

    (University of Exeter Medical School, University of Exeter, RILD Building, Barrack Road)

  • Jonathan Mill

    (University of Exeter Medical School, University of Exeter, RILD Building, Barrack Road
    Institute of Psychiatry, King’s College London)

  • Daniel H. Geschwind

    (David Geffen School of Medicine, University of California Los Angeles
    Neurogenetics Program, David Geffen School of Medicine, University of California Los Angeles
    Center for Autism Research and Treatment, Semel Institute, David Geffen School of Medicine, University of California Los Angeles)

  • Steve Horvath

    (David Geffen School of Medicine, University of California Los Angeles
    School of Public Health, University of California Los Angeles)

Abstract

Identifying genes regulating the pace of epigenetic ageing represents a new frontier in genome-wide association studies (GWASs). Here using 1,796 brain samples from 1,163 individuals, we carry out a GWAS of two DNA methylation-based biomarkers of brain age: the epigenetic ageing rate and estimated proportion of neurons. Locus 17q11.2 is significantly associated (P=4.5 × 10−9) with the ageing rate across five brain regions and harbours a cis-expression quantitative trait locus for EFCAB5 (P=3.4 × 10−20). Locus 1p36.12 is significantly associated (P=2.2 × 10−8) with epigenetic ageing of the prefrontal cortex, independent of the proportion of neurons. Our GWAS of the proportion of neurons identified two genome-wide significant loci (10q26 and 12p13.31) and resulted in a gene set that overlaps significantly with sets found by GWAS of age-related macular degeneration (P=1.4 × 10−12), ulcerative colitis (P

Suggested Citation

  • Ake T. Lu & Eilis Hannon & Morgan E. Levine & Eileen M. Crimmins & Katie Lunnon & Jonathan Mill & Daniel H. Geschwind & Steve Horvath, 2017. "Genetic architecture of epigenetic and neuronal ageing rates in human brain regions," Nature Communications, Nature, vol. 8(1), pages 1-14, August.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15353
    DOI: 10.1038/ncomms15353
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms15353
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms15353?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15353. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.