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Underwater Leidenfrost nanochemistry for creation of size-tailored zinc peroxide cancer nanotherapeutics

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  • Mady Elbahri

    (Nanochemistry and Nanoengineering, School of Chemical Engineering, Aalto University
    Nanochemistry and Nanoengineering, Institute for Materials Science, Faculty of Engineering, Kiel University
    Center for Nanotechnology, Zewail City of Science and Technology)

  • Ramzy Abdelaziz

    (Nanochemistry and Nanoengineering, School of Chemical Engineering, Aalto University)

  • Duygu Disci-Zayed

    (Nanochemistry and Nanoengineering, Institute for Materials Science, Faculty of Engineering, Kiel University
    Faculty of Technology and Bionics, Rhine-Waal University of Applied Sciences)

  • Shahin Homaeigohar

    (Nanochemistry and Nanoengineering, School of Chemical Engineering, Aalto University)

  • Justyna Sosna

    (Institute of Immunology, Kiel University
    University of California)

  • Dieter Adam

    (Institute of Immunology, Kiel University)

  • Lorenz Kienle

    (Synthesis and Real Structure, Institute for Materials Science, Faculty of Engineering, Kiel University)

  • Torben Dankwort

    (Synthesis and Real Structure, Institute for Materials Science, Faculty of Engineering, Kiel University)

  • Moheb Abdelaziz

    (Nanochemistry and Nanoengineering, School of Chemical Engineering, Aalto University
    Nanochemistry and Nanoengineering, Institute for Materials Science, Faculty of Engineering, Kiel University)

Abstract

The dynamic underwater chemistry seen in nature is inspiring for the next generation of eco-friendly nanochemistry. In this context, green synthesis of size-tailored nanoparticles in a facile and scalable manner via a dynamic process is an interesting challenge. Simulating the volcano-induced dynamic chemistry of the deep ocean, here we demonstrate the Leidenfrost dynamic chemistry occurring in an underwater overheated confined zone as a new tool for customized creation of nanoclusters of zinc peroxide. The hydrodynamic nature of the phenomenon ensures eruption of the nanoclusters towards a much colder region, giving rise to growth of monodisperse, size-tailored nanoclusters. Such nanoparticles are investigated in terms of their cytotoxicity on suspension and adherent cells to prove their applicability as cancer nanotherapeutics. Our research can pave the way for employment of the dynamic green nanochemistry in facile, scalable fabrication of size-tailored nanoparticles for biomedical applications.

Suggested Citation

  • Mady Elbahri & Ramzy Abdelaziz & Duygu Disci-Zayed & Shahin Homaeigohar & Justyna Sosna & Dieter Adam & Lorenz Kienle & Torben Dankwort & Moheb Abdelaziz, 2017. "Underwater Leidenfrost nanochemistry for creation of size-tailored zinc peroxide cancer nanotherapeutics," Nature Communications, Nature, vol. 8(1), pages 1-10, August.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15319
    DOI: 10.1038/ncomms15319
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