IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v8y2017i1d10.1038_ncomms15314.html
   My bibliography  Save this article

Engineered clearing agents for the selective depletion of antigen-specific antibodies

Author

Listed:
  • Siva Charan Devanaboyina

    (Texas A&M University Health Science Center
    Texas A&M University Health Science Center)

  • Priyanka Khare

    (Texas A&M University Health Science Center
    Texas A&M University Health Science Center)

  • Dilip K. Challa

    (Texas A&M University Health Science Center
    Texas A&M University Health Science Center)

  • Raimund J. Ober

    (Texas A&M University Health Science Center
    Texas A&M University)

  • E. Sally Ward

    (Texas A&M University Health Science Center
    Texas A&M University Health Science Center)

Abstract

Here we have designed a novel class of engineered antibody-based reagents (‘Seldegs’) that induce the selective degradation of antigen-specific antibodies. We demonstrate the rapid and specific clearance of antibodies recognizing the autoantigen, myelin oligodendrocyte glycoprotein and tumour target, HER2. Seldegs have considerable potential in multiple areas, including the treatment of antibody-mediated autoimmunity and diagnostic imaging.

Suggested Citation

  • Siva Charan Devanaboyina & Priyanka Khare & Dilip K. Challa & Raimund J. Ober & E. Sally Ward, 2017. "Engineered clearing agents for the selective depletion of antigen-specific antibodies," Nature Communications, Nature, vol. 8(1), pages 1-6, August.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15314
    DOI: 10.1038/ncomms15314
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms15314
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms15314?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15314. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.