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TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice

Author

Listed:
  • Maria Cristina Marrone

    (European Brain Research Institute-Fondazione Rita Levi Montalcini
    IRCCS Fondazione Santa Lucia)

  • Annunziato Morabito

    (European Brain Research Institute-Fondazione Rita Levi Montalcini
    Sapienza University of Rome)

  • Michela Giustizieri

    (European Brain Research Institute-Fondazione Rita Levi Montalcini
    IRCCS Fondazione Santa Lucia)

  • Valerio Chiurchiù

    (IRCCS Fondazione Santa Lucia
    Campus Bio-Medico University of Rome)

  • Alessandro Leuti

    (IRCCS Fondazione Santa Lucia)

  • Marzia Mattioli

    (European Brain Research Institute-Fondazione Rita Levi Montalcini
    IRCCS Fondazione Santa Lucia)

  • Sara Marinelli

    (European Brain Research Institute-Fondazione Rita Levi Montalcini
    CNR-National Research Council, Institute of Cell Biology and Neurobiology)

  • Loredana Riganti

    (CNR Institute of Neuroscience, via Vanvitelli 32)

  • Marta Lombardi

    (IRCCS Humanitas, via Manzoni 56)

  • Emanuele Murana

    (Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University of Rome)

  • Antonio Totaro

    (IRCCS Fondazione Santa Lucia)

  • Daniele Piomelli

    (Drug Discovery and Development, Fondazione Istituto Italiano di Tecnologia)

  • Davide Ragozzino

    (Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University of Rome
    IRCCS Neuromed)

  • Sergio Oddi

    (IRCCS Fondazione Santa Lucia
    Faculty of Veterinary Medicine, University of Teramo)

  • Mauro Maccarrone

    (IRCCS Fondazione Santa Lucia
    Campus Bio-Medico University of Rome)

  • Claudia Verderio

    (CNR-National Research Council, Institute of Cell Biology and Neurobiology
    CNR Institute of Neuroscience, via Vanvitelli 32)

  • Silvia Marinelli

    (European Brain Research Institute-Fondazione Rita Levi Montalcini
    IRCCS Fondazione Santa Lucia)

Abstract

The capsaicin receptor TRPV1 has been widely characterized in the sensory system as a key component of pain and inflammation. A large amount of evidence shows that TRPV1 is also functional in the brain although its role is still debated. Here we report that TRPV1 is highly expressed in microglial cells rather than neurons of the anterior cingulate cortex and other brain areas. We found that stimulation of microglial TRPV1 controls cortical microglia activation per se and indirectly enhances glutamatergic transmission in neurons by promoting extracellular microglial microvesicles shedding. Conversely, in the cortex of mice suffering from neuropathic pain, TRPV1 is also present in neurons affecting their intrinsic electrical properties and synaptic strength. Altogether, these findings identify brain TRPV1 as potential detector of harmful stimuli and a key player of microglia to neuron communication.

Suggested Citation

  • Maria Cristina Marrone & Annunziato Morabito & Michela Giustizieri & Valerio Chiurchiù & Alessandro Leuti & Marzia Mattioli & Sara Marinelli & Loredana Riganti & Marta Lombardi & Emanuele Murana & Ant, 2017. "TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice," Nature Communications, Nature, vol. 8(1), pages 1-18, August.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15292
    DOI: 10.1038/ncomms15292
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