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Sara phosphorylation state controls the dispatch of endosomes from the central spindle during asymmetric division

Author

Listed:
  • Sylvain Loubéry

    (University of Geneva)

  • Alicia Daeden

    (University of Geneva)

  • Carole Seum

    (University of Geneva)

  • Laurent Holtzer

    (University of Geneva)

  • Ana Moraleda

    (University of Geneva)

  • Nicolas Damond

    (University of Geneva)

  • Emmanuel Derivery

    (University of Geneva)

  • Thomas Schmidt

    (University of Geneva)

  • Marcos Gonzalez-Gaitan

    (University of Geneva)

Abstract

During asymmetric division, fate assignation in daughter cells is mediated by the partition of determinants from the mother. In the fly sensory organ precursor cell, Notch signalling partitions into the pIIa daughter. Notch and its ligand Delta are endocytosed into Sara endosomes in the mother cell and they are first targeted to the central spindle, where they get distributed asymmetrically to finally be dispatched to pIIa. While the processes of endosomal targeting and asymmetry are starting to be understood, the machineries implicated in the final dispatch to pIIa are unknown. We show that Sara binds the PP1c phosphatase and its regulator Sds22. Sara phosphorylation on three specific sites functions as a switch for the dispatch: if not phosphorylated, endosomes are targeted to the spindle and upon phosphorylation of Sara, endosomes detach from the spindle during pIIa targeting.

Suggested Citation

  • Sylvain Loubéry & Alicia Daeden & Carole Seum & Laurent Holtzer & Ana Moraleda & Nicolas Damond & Emmanuel Derivery & Thomas Schmidt & Marcos Gonzalez-Gaitan, 2017. "Sara phosphorylation state controls the dispatch of endosomes from the central spindle during asymmetric division," Nature Communications, Nature, vol. 8(1), pages 1-11, August.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15285
    DOI: 10.1038/ncomms15285
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