IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v8y2017i1d10.1038_ncomms15242.html
   My bibliography  Save this article

An in vivo strategy to counteract post-administration anticoagulant activity of azido-Warfarin

Author

Listed:
  • Sylvain Ursuegui

    (Laboratory of Functional Chemo-Systems (UMR 7199), Labex Medalis, University of Strasbourg)

  • Marion Recher

    (Laboratory of Functional Chemo-Systems (UMR 7199), Labex Medalis, University of Strasbourg)

  • Wojciech Krężel

    (Institut de Génétique et de Biologie Moléculaire et Cellulaire
    Institut de la Santé et de la Recherche Médicale
    Centre National de la Recherche Scientifique
    Université de Strasbourg)

  • Alain Wagner

    (Laboratory of Functional Chemo-Systems (UMR 7199), Labex Medalis, University of Strasbourg)

Abstract

Drugs, usually long acting and metabolically stable molecules, might be the source of adverse effects triggered by complex drug interactions, anaphylaxis and drug-induced coagulopathy. To circumvent this growing drug safety issue, we herein investigate the opportunity offered by bio-orthogonal chemistry for in vivo drug neutralization. We design a small-molecule anticoagulant drug (Warfarin) containing an azide group that acts as a safety pin. It allows drug deactivation and restoration of physiological coagulation via in vivo click reaction with a suitable cyclooctyne-based neutralizing agent. In this strategy, the new molecule formed by reaction of the drug and the antidote is deprived of biological activity and prone to fast renal clearance. This ‘Click & Clear’ approach lays ground for new strategies in designing drugs with switchable biophysical properties.

Suggested Citation

  • Sylvain Ursuegui & Marion Recher & Wojciech Krężel & Alain Wagner, 2017. "An in vivo strategy to counteract post-administration anticoagulant activity of azido-Warfarin," Nature Communications, Nature, vol. 8(1), pages 1-8, August.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15242
    DOI: 10.1038/ncomms15242
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms15242
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms15242?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15242. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.