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Induction of resident memory T cells enhances the efficacy of cancer vaccine

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  • Mevyn Nizard

    (INSERM U970, Université Paris Descartes, Sorbonne Paris-Cité
    Equipe Labellisée Ligue Contre le Cancer)

  • Hélène Roussel

    (INSERM U970, Université Paris Descartes, Sorbonne Paris-Cité
    Equipe Labellisée Ligue Contre le Cancer
    Hopital Européen Georges Pompidou)

  • Mariana O. Diniz

    (INSERM U970, Université Paris Descartes, Sorbonne Paris-Cité
    Institute of Biomedical Sciences, University of Sao Paulo, Av Prof Lineu Prestes)

  • Soumaya Karaki

    (INSERM U970, Université Paris Descartes, Sorbonne Paris-Cité
    Equipe Labellisée Ligue Contre le Cancer)

  • Thi Tran

    (INSERM U970, Université Paris Descartes, Sorbonne Paris-Cité
    Equipe Labellisée Ligue Contre le Cancer)

  • Thibault Voron

    (INSERM U970, Université Paris Descartes, Sorbonne Paris-Cité
    Equipe Labellisée Ligue Contre le Cancer)

  • Estelle Dransart

    (Institut Curie, PSL Research University, Chemical Biology of Membranes and Therapeutic Delivery Unit)

  • Federico Sandoval

    (INSERM U970, Université Paris Descartes, Sorbonne Paris-Cité
    Equipe Labellisée Ligue Contre le Cancer)

  • Marc Riquet

    (Hopital Europeen Georges Pompidou, Chrirurgie Thoracique Générale, Oncologique et Transplantation)

  • Bastien Rance

    (Hopital Européen Georges Pompidou)

  • Elie Marcheteau

    (INSERM U970, Université Paris Descartes, Sorbonne Paris-Cité
    Equipe Labellisée Ligue Contre le Cancer)

  • Elizabeth Fabre

    (Departement of Medical Oncology, Hopital Européen Georges Pompidou)

  • Marion Mandavit

    (INSERM U970, Université Paris Descartes, Sorbonne Paris-Cité
    Equipe Labellisée Ligue Contre le Cancer)

  • Magali Terme

    (INSERM U970, Université Paris Descartes, Sorbonne Paris-Cité
    Equipe Labellisée Ligue Contre le Cancer)

  • Charlotte Blanc

    (INSERM U970, Université Paris Descartes, Sorbonne Paris-Cité
    Equipe Labellisée Ligue Contre le Cancer)

  • Jean-Baptiste Escudie

    (Hopital Européen Georges Pompidou)

  • Laure Gibault

    (Hopital Européen Georges Pompidou)

  • Françoise Le Pimpec Barthes

    (Hopital Europeen Georges Pompidou, Chrirurgie Thoracique Générale, Oncologique et Transplantation)

  • Clemence Granier

    (INSERM U970, Université Paris Descartes, Sorbonne Paris-Cité
    Equipe Labellisée Ligue Contre le Cancer)

  • Luis C. S. Ferreira

    (Institute of Biomedical Sciences, University of Sao Paulo, Av Prof Lineu Prestes)

  • Cecile Badoual

    (INSERM U970, Université Paris Descartes, Sorbonne Paris-Cité
    Equipe Labellisée Ligue Contre le Cancer
    Hopital Européen Georges Pompidou)

  • Ludger Johannes

    (Institut Curie, PSL Research University, Chemical Biology of Membranes and Therapeutic Delivery Unit)

  • Eric Tartour

    (INSERM U970, Université Paris Descartes, Sorbonne Paris-Cité
    Equipe Labellisée Ligue Contre le Cancer
    Hopital Européen Georges Pompidou)

Abstract

Tissue-resident memory T cells (Trm) represent a new subset of long-lived memory T cells that remain in tissue and do not recirculate. Although they are considered as early immune effectors in infectious diseases, their role in cancer immunosurveillance remains unknown. In a preclinical model of head and neck cancer, we show that intranasal vaccination with a mucosal vector, the B subunit of Shiga toxin, induces local Trm and inhibits tumour growth. As Trm do not recirculate, we demonstrate their crucial role in the efficacy of cancer vaccine with parabiosis experiments. Blockade of TFGβ decreases the induction of Trm after mucosal vaccine immunization, resulting in the lower efficacy of cancer vaccine. In order to extrapolate this role of Trm in humans, we show that the number of Trm correlates with a better overall survival in lung cancer in multivariate analysis. The induction of Trm may represent a new surrogate biomarker for the efficacy of cancer vaccine. This study also argues for the development of vaccine strategies designed to elicit them.

Suggested Citation

  • Mevyn Nizard & Hélène Roussel & Mariana O. Diniz & Soumaya Karaki & Thi Tran & Thibault Voron & Estelle Dransart & Federico Sandoval & Marc Riquet & Bastien Rance & Elie Marcheteau & Elizabeth Fabre &, 2017. "Induction of resident memory T cells enhances the efficacy of cancer vaccine," Nature Communications, Nature, vol. 8(1), pages 1-11, August.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15221
    DOI: 10.1038/ncomms15221
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    Cited by:

    1. Curtis J. Pritzl & Dezzarae Luera & Karin M. Knudson & Michael J. Quaney & Michael J. Calcutt & Mark A. Daniels & Emma Teixeiro, 2023. "IKK2/NFkB signaling controls lung resident CD8+ T cell memory during influenza infection," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Qingnan Zhao & Jiemiao Hu & Lingyuan Kong & Shan Jiang & Xiangjun Tian & Jing Wang & Rintaro Hashizume & Zhiliang Jia & Natalie Wall Fowlkes & Jun Yan & Xueqing Xia & Sofia F. Yi & Long Hoang Dao & Da, 2023. "FGL2-targeting T cells exhibit antitumor effects on glioblastoma and recruit tumor-specific brain-resident memory T cells," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    3. Guo Li & Saranya Srinivasan & Liwen Wang & Chaoyu Ma & Kai Guo & Wenhao Xiao & Wei Liao & Shruti Mishra & Xin Zhang & Yuanzheng Qiu & Qianjin Lu & Yong Liu & Nu Zhang, 2022. "TGF-β-dependent lymphoid tissue residency of stem-like T cells limits response to tumor vaccine," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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