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Senescent tumor cells lead the collective invasion in thyroid cancer

Author

Listed:
  • Young Hwa Kim

    (Ajou University, School of Medicine)

  • Yong Won Choi

    (Ajou University, School of Medicine
    Ajou University School of Medicine)

  • Jeonghun Lee

    (Ajou University School of Medicine)

  • Euy Young Soh

    (Ajou University School of Medicine)

  • Jang-Hee Kim

    (Ajou University School of Medicine)

  • Tae Jun Park

    (Ajou University, School of Medicine)

Abstract

Cellular senescence has been perceived as a barrier against carcinogenesis. However, the senescence-associated secretory phenotype (SASP) of senescent cells can promote tumorigenesis. Here, we show senescent tumour cells are frequently present in the front region of collective invasion of papillary thyroid carcinoma (PTC), as well as lymphatic channels and metastatic foci of lymph nodes. In in vitro invasion analysis, senescent tumour cells exhibit high invasion ability as compared with non-senescent tumour cells through SASP expression. Collective invasion in PTC is led by senescent tumour cells characterized by generation of a C-X-C-motif ligand (CXCL)12 chemokine gradient in the front region. Furthermore, senescent cells increase the survival of cancer cells via CXCL12/CXCR4 signalling. An orthotopic xenograft in vivo model also shows higher lymphatic vessels involvement in the group co-transplanted with senescent cells and cancer cells. These findings suggest that senescent cells are actively involved in the collective invasion and metastasis of PTC.

Suggested Citation

  • Young Hwa Kim & Yong Won Choi & Jeonghun Lee & Euy Young Soh & Jang-Hee Kim & Tae Jun Park, 2017. "Senescent tumor cells lead the collective invasion in thyroid cancer," Nature Communications, Nature, vol. 8(1), pages 1-14, August.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15208
    DOI: 10.1038/ncomms15208
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    Cited by:

    1. Antoine A. Khalil & Daan Smits & Peter D. Haughton & Thijs Koorman & Karin A. Jansen & Mathijs P. Verhagen & Mirjam Net & Kitty Zwieten & Lotte Enserink & Lisa Jansen & Abdelrahman G. El-Gammal & Daan, 2024. "A YAP-centered mechanotransduction loop drives collective breast cancer cell invasion," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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