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Hundreds of dual-stage antimalarial molecules discovered by a functional gametocyte screen

Author

Listed:
  • Celia Miguel-Blanco

    (Diseases of the Developing World (DDW), GlaxoSmithKline
    Imperial College of London)

  • Irene Molina

    (Diseases of the Developing World (DDW), GlaxoSmithKline)

  • Ana I. Bardera

    (Molecular Discovery Research (MDR), GlaxoSmithKline)

  • Beatriz Díaz

    (Diseases of the Developing World (DDW), GlaxoSmithKline)

  • Laura de las Heras

    (Diseases of the Developing World (DDW), GlaxoSmithKline)

  • Sonia Lozano

    (Diseases of the Developing World (DDW), GlaxoSmithKline)

  • Carolina González

    (Diseases of the Developing World (DDW), GlaxoSmithKline)

  • Janneth Rodrigues

    (Diseases of the Developing World (DDW), GlaxoSmithKline)

  • Michael J. Delves

    (Imperial College of London)

  • Andrea Ruecker

    (Imperial College of London
    Present address: Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand and Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK)

  • Gonzalo Colmenarejo

    (Molecular Discovery Research (MDR), GlaxoSmithKline)

  • Sara Viera

    (Diseases of the Developing World (DDW), GlaxoSmithKline)

  • María S. Martínez-Martínez

    (Diseases of the Developing World (DDW), GlaxoSmithKline)

  • Esther Fernández

    (Diseases of the Developing World (DDW), GlaxoSmithKline)

  • Jake Baum

    (Imperial College of London)

  • Robert E. Sinden

    (Imperial College of London)

  • Esperanza Herreros

    (Diseases of the Developing World (DDW), GlaxoSmithKline)

Abstract

Plasmodium falciparum stage V gametocytes are responsible for parasite transmission, and drugs targeting this stage are needed to support malaria elimination. We here screen the Tres Cantos Antimalarial Set (TCAMS) using the previously developed P. falciparum female gametocyte activation assay (Pf FGAA), which assesses stage V female gametocyte viability and functionality using Pfs25 expression. We identify over 400 compounds with activities

Suggested Citation

  • Celia Miguel-Blanco & Irene Molina & Ana I. Bardera & Beatriz Díaz & Laura de las Heras & Sonia Lozano & Carolina González & Janneth Rodrigues & Michael J. Delves & Andrea Ruecker & Gonzalo Colmenarej, 2017. "Hundreds of dual-stage antimalarial molecules discovered by a functional gametocyte screen," Nature Communications, Nature, vol. 8(1), pages 1-10, August.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15160
    DOI: 10.1038/ncomms15160
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