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Antibody-powered nucleic acid release using a DNA-based nanomachine

Author

Listed:
  • Simona Ranallo

    (University of Rome, Tor Vergata, Via della Ricerca Scientifica)

  • Carl Prévost-Tremblay

    (Laboratory of Biosensors and Nanomachines, Départment de Biochimie et Médecine Moléculaire, Université de Montréal)

  • Andrea Idili

    (University of Rome, Tor Vergata, Via della Ricerca Scientifica)

  • Alexis Vallée-Bélisle

    (Laboratory of Biosensors and Nanomachines, Départment de Biochimie et Médecine Moléculaire, Université de Montréal)

  • Francesco Ricci

    (University of Rome, Tor Vergata, Via della Ricerca Scientifica)

Abstract

A wide range of molecular devices with nanoscale dimensions have been recently designed to perform a variety of functions in response to specific molecular inputs. Only limited examples, however, utilize antibodies as regulatory inputs. In response to this, here we report the rational design of a modular DNA-based nanomachine that can reversibly load and release a molecular cargo on binding to a specific antibody. We show here that, by using three different antigens (including one relevant to HIV), it is possible to design different DNA nanomachines regulated by their targeting antibody in a rapid, versatile and highly specific manner. The antibody-powered DNA nanomachines we have developed here may thus be useful in applications like controlled drug-release, point-of-care diagnostics and in vivo imaging.

Suggested Citation

  • Simona Ranallo & Carl Prévost-Tremblay & Andrea Idili & Alexis Vallée-Bélisle & Francesco Ricci, 2017. "Antibody-powered nucleic acid release using a DNA-based nanomachine," Nature Communications, Nature, vol. 8(1), pages 1-9, August.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15150
    DOI: 10.1038/ncomms15150
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    Cited by:

    1. Yuan Liang & Yunkai Qie & Jing Yang & Ranfeng Wu & Shuang Cui & Yuliang Zhao & Greg J. Anderson & Guangjun Nie & Suping Li & Cheng Zhang, 2023. "Programming conformational cooperativity to regulate allosteric protein-oligonucleotide signal transduction," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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