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Gold nanoclusters-assisted delivery of NGF siRNA for effective treatment of pancreatic cancer

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  • Yifeng Lei

    (Beijing Engineering Research Center for BioNanotechnology and CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for NanoScience and Technology
    Present address: Cross-Disciplinary Institute of Engineering Sciences, School of Power and Mechanical Engineering, Wuhan University, Wuhan 430072, China)

  • Lixue Tang

    (Beijing Engineering Research Center for BioNanotechnology and CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for NanoScience and Technology)

  • Yangzhouyun Xie

    (Beijing Engineering Research Center for BioNanotechnology and CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for NanoScience and Technology)

  • Yunlei Xianyu

    (Beijing Engineering Research Center for BioNanotechnology and CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for NanoScience and Technology)

  • Lingmin Zhang

    (Beijing Engineering Research Center for BioNanotechnology and CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for NanoScience and Technology)

  • Peng Wang

    (Beijing Engineering Research Center for BioNanotechnology and CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for NanoScience and Technology)

  • Yoh Hamada

    (Graduate School of Medicine, Tohoku University)

  • Kai Jiang

    (Chinese PLA General Hospital)

  • Wenfu Zheng

    (Beijing Engineering Research Center for BioNanotechnology and CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for NanoScience and Technology)

  • Xingyu Jiang

    (Beijing Engineering Research Center for BioNanotechnology and CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for NanoScience and Technology
    University of Chinese Academy of Sciences)

Abstract

Pancreatic cancer is one of the deadliest human cancers, whose progression is highly dependent on the nervous microenvironment. The suppression of gene expression of nerve growth factor (NGF) may have great potential in pancreatic cancer treatment. Here we show that gold nanocluster-assisted delivery of siRNA of NGF (GNC–siRNA) allows efficient NGF gene silencing and pancreatic cancer treatment. The GNC–siRNA complex increases the stability of siRNA in serum, prolongs the circulation lifetime of siRNA in blood and enhances the cellular uptake and tumour accumulation of siRNA. The GNC–siRNA complex potently downregulates the NGF expression in Panc-1 cells and in pancreatic tumours, and effectively inhibits the tumour progression in three pancreatic tumour models (subcutaneous model, orthotopic model and patient-derived xenograft model) without adverse effects. Our study constitutes a straightforward but effective approach to inhibit pancreatic cancer via NGF knockdown, suggesting a promising therapeutic direction for pancreatic cancer.

Suggested Citation

  • Yifeng Lei & Lixue Tang & Yangzhouyun Xie & Yunlei Xianyu & Lingmin Zhang & Peng Wang & Yoh Hamada & Kai Jiang & Wenfu Zheng & Xingyu Jiang, 2017. "Gold nanoclusters-assisted delivery of NGF siRNA for effective treatment of pancreatic cancer," Nature Communications, Nature, vol. 8(1), pages 1-15, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15130
    DOI: 10.1038/ncomms15130
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    Cited by:

    1. Meng Guan & Kai Cheng & Xiao-Ting Xie & Yong Li & Meng-Wen Ma & Bin Zhang & Si Chen & Wei Chen & Bo Liu & Jin-Xuan Fan & Yuan-Di Zhao, 2024. "Regulating copper homeostasis of tumor cells to promote cuproptosis for enhancing breast cancer immunotherapy," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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