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Noumeavirus replication relies on a transient remote control of the host nucleus

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  • Elisabeth Fabre

    (Aix–Marseille University, Centre National de la Recherche Scientifique, Information Génomique & Structurale, Unité Mixte de Recherche 7256 (Institut de Microbiologie de la Méditerranée, FR3479))

  • Sandra Jeudy

    (Aix–Marseille University, Centre National de la Recherche Scientifique, Information Génomique & Structurale, Unité Mixte de Recherche 7256 (Institut de Microbiologie de la Méditerranée, FR3479))

  • Sébastien Santini

    (Aix–Marseille University, Centre National de la Recherche Scientifique, Information Génomique & Structurale, Unité Mixte de Recherche 7256 (Institut de Microbiologie de la Méditerranée, FR3479))

  • Matthieu Legendre

    (Aix–Marseille University, Centre National de la Recherche Scientifique, Information Génomique & Structurale, Unité Mixte de Recherche 7256 (Institut de Microbiologie de la Méditerranée, FR3479))

  • Mathieu Trauchessec

    (Université Grenoble Alpes, BIG-BGE
    Commissariat à l’Energie Atomique, BIG-BGE
    INSERM, BGE)

  • Yohann Couté

    (Université Grenoble Alpes, BIG-BGE
    Commissariat à l’Energie Atomique, BIG-BGE
    INSERM, BGE)

  • Jean-Michel Claverie

    (Aix–Marseille University, Centre National de la Recherche Scientifique, Information Génomique & Structurale, Unité Mixte de Recherche 7256 (Institut de Microbiologie de la Méditerranée, FR3479)
    Assistance Publique – Hôpitaux de Marseille)

  • Chantal Abergel

    (Aix–Marseille University, Centre National de la Recherche Scientifique, Information Génomique & Structurale, Unité Mixte de Recherche 7256 (Institut de Microbiologie de la Méditerranée, FR3479))

Abstract

Acanthamoeba are infected by a remarkable diversity of large dsDNA viruses, the infectious cycles of which have been characterized using genomics, transcriptomics and electron microscopy. Given their gene content and the persistence of the host nucleus throughout their infectious cycle, the Marseilleviridae were initially assumed to fully replicate in the cytoplasm. Unexpectedly, we find that their virions do not incorporate the virus-encoded transcription machinery, making their replication nucleus-dependent. However, instead of delivering their DNA to the nucleus, the Marseilleviridae initiate their replication by transiently recruiting the nuclear transcription machinery to their cytoplasmic viral factory. The nucleus recovers its integrity after becoming leaky at an early stage. This work highlights the importance of virion proteomic analyses to complement genome sequencing in the elucidation of the replication scheme and evolution of large dsDNA viruses.

Suggested Citation

  • Elisabeth Fabre & Sandra Jeudy & Sébastien Santini & Matthieu Legendre & Mathieu Trauchessec & Yohann Couté & Jean-Michel Claverie & Chantal Abergel, 2017. "Noumeavirus replication relies on a transient remote control of the host nucleus," Nature Communications, Nature, vol. 8(1), pages 1-12, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15087
    DOI: 10.1038/ncomms15087
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    Cited by:

    1. Hugo Bisio & Matthieu Legendre & Claire Giry & Nadege Philippe & Jean-Marie Alempic & Sandra Jeudy & Chantal Abergel, 2023. "Evolution of giant pandoravirus revealed by CRISPR/Cas9," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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