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Activation of the hypothalamic feeding centre upon visual prey detection

Author

Listed:
  • Akira Muto

    (National Institute of Genetics, SOKENDAI (The Graduate University for Advanced Studies))

  • Pradeep Lal

    (National Institute of Genetics, SOKENDAI (The Graduate University for Advanced Studies)
    Present address: The Kavli Institute for Systems Neuroscience/Centre for Neural Computation, NTNU Faculty of Medicine, Olav Kyrres g 9, Trondheim 7030, Norway)

  • Deepak Ailani

    (National Institute of Genetics, SOKENDAI (The Graduate University for Advanced Studies))

  • Gembu Abe

    (National Institute of Genetics, SOKENDAI (The Graduate University for Advanced Studies)
    Present address: Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Katahira 2-1-1 Aoba-ku, Sendai, Miyagi 980-8577, Japan)

  • Mari Itoh

    (National Institute of Genetics, SOKENDAI (The Graduate University for Advanced Studies))

  • Koichi Kawakami

    (National Institute of Genetics, SOKENDAI (The Graduate University for Advanced Studies))

Abstract

The visual system plays a major role in food/prey recognition in diurnal animals, and food intake is regulated by the hypothalamus. However, whether and how visual information about prey is conveyed to the hypothalamic feeding centre is largely unknown. Here we perform real-time imaging of neuronal activity in freely behaving or constrained zebrafish larvae and demonstrate that prey or prey-like visual stimuli activate the hypothalamic feeding centre. Furthermore, we identify prey detector neurons in the pretectal area that project to the hypothalamic feeding centre. Ablation of the pretectum completely abolishes prey capture behaviour and neurotoxin expression in the hypothalamic area also reduces feeding. Taken together, these results suggest that the pretecto-hypothalamic pathway plays a crucial role in conveying visual information to the feeding centre. Thus, this pathway possibly converts visual food detection into feeding motivation in zebrafish.

Suggested Citation

  • Akira Muto & Pradeep Lal & Deepak Ailani & Gembu Abe & Mari Itoh & Koichi Kawakami, 2017. "Activation of the hypothalamic feeding centre upon visual prey detection," Nature Communications, Nature, vol. 8(1), pages 1-10, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15029
    DOI: 10.1038/ncomms15029
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    Cited by:

    1. Thomas Juan & Agatha Ribeiro da Silva & Bárbara Cardoso & SoEun Lim & Violette Charteau & Didier Y. R. Stainier, 2023. "Multiple pkd and piezo gene family members are required for atrioventricular valve formation," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Maria E Yurgel & Priyanka Kakad & Meet Zandawala & Dick R Nässel & Tanja A Godenschwege & Alex C Keene, 2019. "A single pair of leucokinin neurons are modulated by feeding state and regulate sleep–metabolism interactions," PLOS Biology, Public Library of Science, vol. 17(2), pages 1-26, February.

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