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Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

Author

Listed:
  • Anne E. Justice

    (University of North Carolina)

  • Thomas W. Winkler

    (Institute of Epidemiology and Preventive Medicine, University of Regensburg)

  • Mary F. Feitosa

    (Washington University School of Medicine)

  • Misa Graff

    (University of North Carolina)

  • Virginia A. Fisher

    (Boston University School of Public Health)

  • Kristin Young

    (University of North Carolina)

  • Llilda Barata

    (Washington University School of Medicine)

  • Xuan Deng

    (Boston University School of Public Health)

  • Jacek Czajkowski

    (Washington University School of Medicine)

  • David Hadley

    (Population Health Research Institute, St. George's, University of London
    TransMed Systems, Inc.)

  • Julius S. Ngwa

    (Boston University School of Public Health
    Johns Hopkins Bloomberg School of Public Health)

  • Tarunveer S. Ahluwalia

    (The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
    Steno Diabetes Center)

  • Audrey Y. Chu

    (NHLBI Framingham Heart Study
    Brigham and Women's Hospital and Harvard Medical School)

  • Nancy L. Heard-Costa

    (NHLBI Framingham Heart Study
    Boston University School of Medicine)

  • Elise Lim

    (Boston University School of Public Health)

  • Jeremiah Perez

    (Boston University School of Public Health)

  • John D. Eicher

    (Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, The Framingham Heart Study)

  • Zoltán Kutalik

    (Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV)
    University of Lausanne
    Swiss instititute of Bioinformatics)

  • Luting Xue

    (Boston University School of Public Health)

  • Anubha Mahajan

    (Wellcome Trust Centre for Human Genetics, University of Oxford)

  • Frida Renström

    (Umeå University
    Genetic and Molecular Epidemiology Unit, Lund University)

  • Joseph Wu

    (Boston University School of Public Health)

  • Qibin Qi

    (Albert Einstein College of Medicine)

  • Shafqat Ahmad

    (Brigham and Women's Hospital and Harvard Medical School
    Genetic and Molecular Epidemiology Unit, Lund University
    Harvard T.H. Chan School of Public Health)

  • Tamuno Alfred

    (The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
    The Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai)

  • Najaf Amin

    (Genetic Epidemiology Unit, Erasmus University Medical Center)

  • Lawrence F. Bielak

    (School of Public Health, University of Michigan)

  • Amelie Bonnefond

    (University of Lille, CNRS, Institut Pasteur of Lille, UMR 8199 - EGID)

  • Jennifer Bragg

    (Internal Medicine - Nephrology, University of Michigan
    University of Michigan)

  • Gemma Cadby

    (Centre for Genetic Origins of Health and Disease, University of Western Australia)

  • Martina Chittani

    (University of Milan)

  • Scott Coggeshall

    (University of Washington)

  • Tanguy Corre

    (Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV)
    University of Lausanne
    Swiss instititute of Bioinformatics)

  • Nese Direk

    (Erasmus Medical Center
    Dokuz Eylul University)

  • Joel Eriksson

    (Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg)

  • Krista Fischer

    (Estonian Genome Center, University of Tartu)

  • Mathias Gorski

    (Institute of Epidemiology and Preventive Medicine, University of Regensburg
    University Hospital Regensburg)

  • Marie Neergaard Harder

    (The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen)

  • Momoko Horikoshi

    (Wellcome Trust Centre for Human Genetics, University of Oxford
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital)

  • Tao Huang

    (Harvard T.H. Chan School of Public Health
    Epidemiology Domain, Saw Swee Hock School of Public Health, National University of Singapore)

  • Jennifer E. Huffman

    (Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, The Framingham Heart Study
    MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh)

  • Anne U. Jackson

    (University of Michigan)

  • Johanne Marie Justesen

    (The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen)

  • Stavroula Kanoni

    (William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London)

  • Leena Kinnunen

    (National Institute for Health and Welfare)

  • Marcus E. Kleber

    (Medical Faculty Mannheim, Heidelberg University)

  • Pirjo Komulainen

    (Kuopio Research Institute of Exercise Medicine)

  • Meena Kumari

    (ISER, University of Essex
    UCL)

  • Unhee Lim

    (Epidemiology Program, University of Hawaii Cancer Center)

  • Jian'an Luan

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science)

  • Leo-Pekka Lyytikäinen

    (Fimlab Laboratories
    Faculty of Medicine and Life Sciences, University of Tampere)

  • Massimo Mangino

    (King’s College London
    NIHR Biomedical Research Centre at Guy’s and St. Thomas’ Foundation Trust)

  • Ani Manichaikul

    (Center for Public Health Genomics and Biostatistics Section, University of Virginia)

  • Jonathan Marten

    (MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh)

  • Rita P. S. Middelberg

    (Genetic Epidemiology, QIMR Berghofer Medical Research Institute)

  • Martina Müller-Nurasyid

    (Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health
    University Hospital Grosshadern, Ludwig-Maximilians-Universität
    DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance)

  • Pau Navarro

    (MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh)

  • Louis Pérusse

    (Faculty of Medicine, Université Laval
    Institute of Nutrition and Functional Foods, Université Laval)

  • Natalia Pervjakova

    (Estonian Genome Center, University of Tartu
    Institute of Molecular and Cell Biology, University of Tartu)

  • Cinzia Sarti

    (City of Helsinki)

  • Albert Vernon Smith

    (Icelandic Heart Association
    Faculty of Medicine, University of Iceland)

  • Jennifer A. Smith

    (School of Public Health, University of Michigan)

  • Alena Stančáková

    (Institute of Clinical Medicine, University of Eastern Finland)

  • Rona J. Strawbridge

    (Cardiovascular Medicine Unit, Karolinska Institutet
    Center for Molecular Medicine, Karolinska University Hospital Solna)

  • Heather M. Stringham

    (University of Michigan)

  • Yun Ju Sung

    (Washington University School of Medicine)

  • Toshiko Tanaka

    (Translational Gerontology Branch, National Institute on Aging)

  • Alexander Teumer

    (Institute for Community Medicine, University Medicine Greifswald)

  • Stella Trompet

    (Leiden University Medical Center
    Leiden University Medical Center)

  • Sander W. van der Laan

    (Laboratory of Experimental Cardiology, UMC Utrecht)

  • Peter J. van der Most

    (University of Groningen, University Medical Center Groningen)

  • Jana V. Van Vliet-Ostaptchouk

    (University of Groningen, University Medical Center Groningen)

  • Sailaja L. Vedantam

    (Boston Children's Hospital
    Broad Institute of Harvard and MIT)

  • Niek Verweij

    (University Medical Center Groningen, University of Groningen)

  • Jacqueline M. Vink

    (Vrije Universiteit
    Behavioural Science Institute, Radboud University)

  • Veronique Vitart

    (MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh)

  • Ying Wu

    (University of North Carolina)

  • Loic Yengo

    (University of Lille, CNRS, Institut Pasteur of Lille, UMR 8199 - EGID)

  • Weihua Zhang

    (Dept Epidemiology and Biostatistics, School of Public Health, Imperical College London
    Cardiology, Ealing Hospital NHS Trust)

  • Jing Hua Zhao

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science)

  • Martina E. Zimmermann

    (Institute of Epidemiology and Preventive Medicine, University of Regensburg)

  • Niha Zubair

    (Fred Hutchinson Cancer Research Center)

  • Gonçalo R. Abecasis

    (University of Michigan)

  • Linda S. Adair

    (Gillings School of Global Public Health, University of North Carolina at Chapel Hill)

  • Saima Afaq

    (Dept Epidemiology and Biostatistics, School of Public Health, Imperical College London
    Cardiology, Ealing Hospital NHS Trust)

  • Uzma Afzal

    (Dept Epidemiology and Biostatistics, School of Public Health, Imperical College London
    Cardiology, Ealing Hospital NHS Trust)

  • Stephan J. L. Bakker

    (University Medical Center Groningen, University of Groningen)

  • Traci M. Bartz

    (University of Washington
    Cardiovascular Health Research Unit, University of Washington)

  • John Beilby

    (Busselton Population Medical Research Institute
    PathWest Laboratory Medicine of WA, Sir Charles Gairdner Hospital
    School of Pathology and Laboraty Medicine, The University of Western Australia)

  • Richard N. Bergman

    (Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center)

  • Sven Bergmann

    (University of Lausanne
    Swiss instititute of Bioinformatics)

  • Reiner Biffar

    (Clinic for Prosthetic Dentistry, Gerostomatology and Material Science, University Medicine Greifswald)

  • John Blangero

    (South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley)

  • Eric Boerwinkle

    (Human Genetics Center, The University of Texas Health Science Center)

  • Lori L. Bonnycastle

    (Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH)

  • Erwin Bottinger

    (The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

  • Daniele Braga

    (University of Milan)

  • Brendan M. Buckley

    (University College Cork)

  • Steve Buyske

    (Rutgers University
    Rutgers University)

  • Harry Campbell

    (Usher Institute for Population Health Sciences and Informatics, The University of Edinburgh)

  • John C. Chambers

    (Dept Epidemiology and Biostatistics, School of Public Health, Imperical College London
    Cardiology, Ealing Hospital NHS Trust
    Imperial College Healthcare NHS Trust)

  • Francis S. Collins

    (Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH)

  • Joanne E. Curran

    (South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley)

  • Gert J. de Borst

    (UMC Utrecht)

  • Anton J. M. de Craen

    (Leiden University Medical Center)

  • Eco J. C. de Geus

    (Vrije Universiteit
    EMGO+ Institute Vrije Universiteit & Vrije Universiteit Medical Center)

  • George Dedoussis

    (School of Health Science and Education, Harokopio University)

  • Graciela E. Delgado

    (Medical Faculty Mannheim, Heidelberg University)

  • Hester M. den Ruijter

    (Laboratory of Experimental Cardiology, UMC Utrecht)

  • Gudny Eiriksdottir

    (Icelandic Heart Association)

  • Anna L. Eriksson

    (Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg)

  • Tõnu Esko

    (Estonian Genome Center, University of Tartu
    Boston Children's Hospital
    Broad Institute of Harvard and MIT)

  • Jessica D. Faul

    (Survey Research Center, Institute for Social Research, University of Michigan)

  • Ian Ford

    (Robertson Centre for Biostatistics, University of Glasgow)

  • Terrence Forrester

    (Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies)

  • Karl Gertow

    (Cardiovascular Medicine Unit, Karolinska Institutet
    Center for Molecular Medicine, Karolinska University Hospital Solna)

  • Bruna Gigante

    (Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet)

  • Nicola Glorioso

    (Hypertension and Related Disease Centre, AOU-University of Sassari)

  • Jian Gong

    (Fred Hutchinson Cancer Research Center)

  • Harald Grallert

    (Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
    Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health
    German Center for Diabetes Research)

  • Tanja B. Grammer

    (Medical Faculty Mannheim, Heidelberg University)

  • Niels Grarup

    (The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen)

  • Saskia Haitjema

    (Laboratory of Experimental Cardiology, UMC Utrecht)

  • Göran Hallmans

    (Section for Nutritional Research, Umeå University)

  • Anders Hamsten

    (Cardiovascular Medicine Unit, Karolinska Institutet
    Center for Molecular Medicine, Karolinska University Hospital Solna)

  • Torben Hansen

    (The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen)

  • Tamara B. Harris

    (Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health)

  • Catharina A. Hartman

    (Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Centre Groningen)

  • Maija Hassinen

    (Kuopio Research Institute of Exercise Medicine)

  • Nicholas D. Hastie

    (MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh)

  • Andrew C. Heath

    (Washington University School of Medicine)

  • Dena Hernandez

    (Laboratory of Neurogenetics, National Institute on Aging)

  • Lucia Hindorff

    (National Human Genome Research Institute, National Institutes of Health)

  • Lynne J. Hocking

    (Institute of Medical Sciences, University of Aberdeen, Foresterhill
    Generation Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh)

  • Mette Hollensted

    (The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen)

  • Oddgeir L. Holmen

    (St. Olav Hospital, Trondheim University Hospital)

  • Georg Homuth

    (Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald)

  • Jouke Jan Hottenga

    (Vrije Universiteit)

  • Jie Huang

    (Wellcome Trust Sanger Institute)

  • Joseph Hung

    (School of Medicine and Pharmacology, The University of Western Australia
    Sir Charles Gairdner Hospital)

  • Nina Hutri-Kähönen

    (Tampere University Hospital
    Faculty of Medicine and Life Sciences, University of Tampere)

  • Erik Ingelsson

    (Molecular Epidemiology, Uppsala University
    Stanford University School of Medicine
    Science for Life Laboratory, Uppsala University)

  • Alan L. James

    (Busselton Population Medical Research Institute
    School of Medicine and Pharmacology, The University of Western Australia
    Sir Charles Gairdner Hospital)

  • John-Olov Jansson

    (Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg)

  • Marjo-Riitta Jarvelin

    (MRC–PHE Centre for Environment & Health, School of Public Health, Imperial College London
    Center for Life Course Epidemiology, Faculty of Medicine, University of Oulu
    Biocenter Oulu, University of Oulu
    Unit of Primary Care, Oulu University Hospital)

  • Min A. Jhun

    (School of Public Health, University of Michigan)

  • Marit E. Jørgensen

    (Steno Diabetes Center)

  • Markus Juonala

    (University of Turku
    Turku University Hospital)

  • Mika Kähönen

    (Tampere University Hospital
    Faculty of Medicine and Life Sciences, University of Tampere)

  • Magnus Karlsson

    (Clinical and Molecular Osteoporosis Research Unit, Skåne University Hospital, Lund University)

  • Heikki A. Koistinen

    (National Institute for Health and Welfare
    University of Helsinki and Helsinki University Central Hospital
    Minerva Foundation Institute for Medical Research, Biomedicum 2U)

  • Ivana Kolcic

    (Faculty of Medicine, University of Split)

  • Genovefa Kolovou

    (Onassis Cardiac Surgery Center)

  • Charles Kooperberg

    (Fred Hutchinson Cancer Research Center)

  • Bernhard K. Krämer

    (Medical Faculty Mannheim, Heidelberg University)

  • Johanna Kuusisto

    (University of Eastern Finland and Kuopio University Hospital)

  • Kirsti Kvaløy

    (HUNT Research Centre, Norwegian University of Science and Technology)

  • Timo A. Lakka

    (Kuopio Research Institute of Exercise Medicine
    Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio Campus)

  • Claudia Langenberg

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science)

  • Lenore J. Launer

    (Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health)

  • Karin Leander

    (Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet)

  • Nanette R. Lee

    (USC-Office of Population Studies Foundation, Inc., University of San Carlos
    Sociology and History, University of San Carlos)

  • Lars Lind

    (Cardiovascular Epidemiology, Uppsala University)

  • Cecilia M. Lindgren

    (Wellcome Trust Centre for Human Genetics, University of Oxford
    Li Ka Shing Centre for Health Information and Discovery, The Big Data Institute, University of Oxford)

  • Allan Linneberg

    (Research Centre for Prevention and Health, the Capital Region of Denmark
    Department of Clinical Experimental Research
    Faculty of Health and Medical Sciences, University of Copenhagen)

  • Stephane Lobbens

    (University of Lille, CNRS, Institut Pasteur of Lille, UMR 8199 - EGID)

  • Marie Loh

    (Dept Epidemiology and Biostatistics, School of Public Health, Imperical College London
    Translational Laboratory in Genetic Medicine (TLGM), Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, Immunos, Level 5)

  • Mattias Lorentzon

    (Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg)

  • Robert Luben

    (University of Cambridge)

  • Gitta Lubke

    (University of Notre Dame)

  • Anja Ludolph-Donislawski

    (Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health
    Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität)

  • Sara Lupoli

    (University of Milan)

  • Pamela A. F. Madden

    (Washington University School of Medicine)

  • Reija Männikkö

    (Kuopio Research Institute of Exercise Medicine)

  • Pedro Marques-Vidal

    (Internal Medicine, Lausanne university hospital (CHUV))

  • Nicholas G. Martin

    (Genetic Epidemiology, QIMR Berghofer Medical Research Institute)

  • Colin A. McKenzie

    (Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies)

  • Barbara McKnight

    (University of Washington
    Cardiovascular Health Research Unit, University of Washington
    Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center)

  • Dan Mellström

    (Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg)

  • Cristina Menni

    (King’s College London)

  • Grant W. Montgomery

    (Molecular Epidemiology, QIMR Berghofer Medical Research Institute)

  • AW (Bill) Musk

    (Busselton Population Medical Research Institute
    School of Population Health, The University of Western Australia
    Sir Charles Gairdner Hospital)

  • Narisu Narisu

    (Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH)

  • Matthias Nauck

    (Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald)

  • Ilja M. Nolte

    (University of Groningen, University Medical Center Groningen)

  • Albertine J. Oldehinkel

    (Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Centre Groningen)

  • Matthias Olden

    (Institute of Epidemiology and Preventive Medicine, University of Regensburg)

  • Ken K. Ong

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science)

  • Sandosh Padmanabhan

    (Generation Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh
    Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow)

  • Patricia A. Peyser

    (School of Public Health, University of Michigan)

  • Charlotta Pisinger

    (Research Center for Prevention and Health, Glostrup Hospital
    Faculty of Health Sciences, University of Copenhagen)

  • David J. Porteous

    (Generation Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh
    Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh)

  • Olli T. Raitakari

    (Turku University Hospital
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku)

  • Tuomo Rankinen

    (Human Genomics Laboratory, Pennington Biomedical Research Center)

  • D. C. Rao

    (Washington University School of Medicine
    Washington University School of Medicine
    Washington University School of Medicine)

  • Laura J. Rasmussen-Torvik

    (Northwestern University Feinberg School of Medicine)

  • Rajesh Rawal

    (Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
    Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health)

  • Treva Rice

    (Washington University School of Medicine
    Washington University School of Medicine)

  • Paul M. Ridker

    (Brigham and Women's Hospital and Harvard Medical School
    Brigham and Women’s Hospital)

  • Lynda M. Rose

    (Brigham and Women's Hospital and Harvard Medical School)

  • Stephanie A. Bien

    (Fred Hutchinson Cancer Research Center)

  • Igor Rudan

    (Usher Institute for Population Health Sciences and Informatics, The University of Edinburgh)

  • Serena Sanna

    (Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale Delle Ricerche (CNR), Cittadella Universitaria di Monserrato)

  • Mark A. Sarzynski

    (Human Genomics Laboratory, Pennington Biomedical Research Center)

  • Naveed Sattar

    (BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine)

  • Kai Savonen

    (Kuopio Research Institute of Exercise Medicine)

  • David Schlessinger

    (Laboratory of Genetics, National Institute on Aging, National Institutes of Health)

  • Salome Scholtens

    (University of Groningen, University Medical Center Groningen)

  • Claudia Schurmann

    (The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
    The Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai)

  • Robert A. Scott

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science)

  • Bengt Sennblad

    (Cardiovascular Medicine Unit, Karolinska Institutet
    Center for Molecular Medicine, Karolinska University Hospital Solna
    Science for Life Laboratory, Karolinska Institutet)

  • Marten A. Siemelink

    (Laboratory of Experimental Cardiology, UMC Utrecht)

  • Günther Silbernagel

    (Medical University of Graz)

  • P Eline Slagboom

    (Leiden University Medical Center)

  • Harold Snieder

    (University of Groningen, University Medical Center Groningen)

  • Jan A. Staessen

    (Research Unit Hypertension and Cardiovascular Epidemiology, University of Leuven, Campus Sint Rafael
    R&D VitaK Group, Maastricht University, Brains Unlimited Building)

  • David J. Stott

    (Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow)

  • Morris A. Swertz

    (University of Groningen, University Medical Center Groningen)

  • Amy J. Swift

    (Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH)

  • Kent D. Taylor

    (Center for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor/UCLA Medical Center
    University of California Los Angeles)

  • Bamidele O. Tayo

    (Stritch School of Medicine, Loyola University of Chicago)

  • Barbara Thorand

    (Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health
    German Center for Diabetes Research)

  • Dorothee Thuillier

    (University of Lille, CNRS, Institut Pasteur of Lille, UMR 8199 - EGID)

  • Jaakko Tuomilehto

    (Dasman Diabetes Institute
    Danube-University Krems
    Saudi Diabetes Research Group, King Abdulaziz University)

  • Andre G. Uitterlinden

    (Erasmus Medical Center
    Erasmus Medical Center)

  • Liesbeth Vandenput

    (Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg)

  • Marie-Claude Vohl

    (Institute of Nutrition and Functional Foods, Université Laval
    School of Nutrition, Université Laval)

  • Henry Völzke

    (Institute for Community Medicine, University Medicine Greifswald)

  • Judith M. Vonk

    (University of Groningen, University Medical Center Groningen)

  • Gérard Waeber

    (Internal Medicine, Lausanne university hospital (CHUV))

  • Melanie Waldenberger

    (Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
    Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health)

  • R. G. J. Westendorp

    (and Center for Healthy Ageing, University of Copenhagen)

  • Sarah Wild

    (Usher Institute for Population Health Sciences and Informatics, The University of Edinburgh)

  • Gonneke Willemsen

    (Vrije Universiteit)

  • Bruce H. R. Wolffenbuttel

    (University of Groningen, University Medical Center Groningen)

  • Andrew Wong

    (MRC Unit for Lifelong Health and Ageing at UCL)

  • Alan F. Wright

    (MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh)

  • Wei Zhao

    (School of Public Health, University of Michigan)

  • M Carola Zillikens

    (Erasmus Medical Center)

  • Damiano Baldassarre

    (Università di Milano
    Centro Cardiologico Monzino, IRCCS)

  • Beverley Balkau

    (Inserm U-1018, CESP)

  • Stefania Bandinelli

    (Geriatric Unit, Azienda USL Toscana centro)

  • Carsten A. Böger

    (University Hospital Regensburg)

  • Dorret I. Boomsma

    (Vrije Universiteit)

  • Claude Bouchard

    (Human Genomics Laboratory, Pennington Biomedical Research Center)

  • Marcel Bruinenberg

    (Lifelines Cohort Study)

  • Daniel I. Chasman

    (Brigham and Women's Hospital and Harvard Medical School
    Brigham and Women’s Hospital)

  • Yii-DerIda Chen

    (Institute for Translational Genomics and Population Sciences, Harbor-UCLA)

  • Peter S. Chines

    (Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH)

  • Richard S. Cooper

    (Stritch School of Medicine, Loyola University of Chicago)

  • Francesco Cucca

    (Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale Delle Ricerche (CNR), Cittadella Universitaria di Monserrato
    Universita' degli Studi di Sassari)

  • Daniele Cusi

    (Sanipedia srl, Bresso (Milano), Italy and Institute of Biomedical Technologies National Centre of Research Segrate)

  • Ulf de Faire

    (Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet)

  • Luigi Ferrucci

    (Translational Gerontology Branch, National Institute on Aging)

  • Paul W. Franks

    (Genetic and Molecular Epidemiology Unit, Lund University
    Harvard T.H. Chan School of Public Health
    Umeå University)

  • Philippe Froguel

    (University of Lille, CNRS, Institut Pasteur of Lille, UMR 8199 - EGID
    Imperial College London)

  • Penny Gordon-Larsen

    (Gillings School of Global Public Health, University of North Carolina at Chapel Hill
    Carolina Population Center, University of North Carolina at Chapel Hill)

  • Hans- Jörgen Grabe

    (University Medicine Greifswald
    German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald)

  • Vilmundur Gudnason

    (Icelandic Heart Association
    Faculty of Medicine, University of Iceland)

  • Christopher A. Haiman

    (Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California)

  • Caroline Hayward

    (MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
    Generation Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh)

  • Kristian Hveem

    (HUNT Research Centre, Norwegian University of Science and Technology)

  • Andrew D. Johnson

    (Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, The Framingham Heart Study)

  • J Wouter Jukema

    (Leiden University Medical Center
    Durrer Center for Cardiogenetic Research
    Interuniversity Cardiology Institute of the Netherlands)

  • Sharon L. R. Kardia

    (School of Public Health, University of Michigan)

  • Mika Kivimaki

    (UCL)

  • Jaspal S. Kooner

    (Cardiology, Ealing Hospital NHS Trust
    Imperial College Healthcare NHS Trust
    Faculty of Med, National Heart & Lung Institute, Cardiovascular Science, Hammersmith Campus, Hammersmith Hospital, Hammersmith Campus, Imperial College London)

  • Diana Kuh

    (MRC Unit for Lifelong Health and Ageing at UCL)

  • Markku Laakso

    (University of Eastern Finland and Kuopio University Hospital)

  • Terho Lehtimäki

    (Fimlab Laboratories
    Faculty of Medicine and Life Sciences, University of Tampere)

  • Loic Le Marchand

    (Epidemiology Program, University of Hawaii Cancer Center)

  • Winfried März

    (Synlab Academy, Synlab Services GmbH
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz)

  • Mark I. McCarthy

    (Wellcome Trust Centre for Human Genetics, University of Oxford
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital
    Oxford National Institute for Health Research (NIHR) Biomedical Research Centre, Churchill Hospital)

  • Andres Metspalu

    (Estonian Genome Center, University of Tartu)

  • Andrew P. Morris

    (Wellcome Trust Centre for Human Genetics, University of Oxford
    University of Liverpool)

  • Claes Ohlsson

    (Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg)

  • Lyle J. Palmer

    (School of Public Health, University of Adelaide)

  • Gerard Pasterkamp

    (Laboratory of Experimental Cardiology, UMC Utrecht
    Laboratory of Clinical Chemistry and Hematology, UMC Utrecht)

  • Oluf Pedersen

    (The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen)

  • Annette Peters

    (Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health
    German Center for Diabetes Research)

  • Ulrike Peters

    (Fred Hutchinson Cancer Research Center)

  • Ozren Polasek

    (Usher Institute for Population Health Sciences and Informatics, The University of Edinburgh
    Faculty of Medicine, University of Split)

  • Bruce M. Psaty

    (University of Washington
    University of Washington
    Group Health Research Institute, Group Health Cooperative)

  • Lu Qi

    (Harvard T.H. Chan School of Public Health
    School of Public Health and Tropical Medicine, Tulane University)

  • Rainer Rauramaa

    (Kuopio Research Institute of Exercise Medicine
    Kuopio University Hospital)

  • Blair H. Smith

    (Generation Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh
    Ninewells Hospital and Medical School, University of Dundee)

  • Thorkild I. A. Sørensen

    (The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
    Bispebjerg and Frederiksberg Hospital (2000 Frederiksberg), The Capital Region
    MRC Integrative Epidemiology Unit, Bristol University)

  • Konstantin Strauch

    (Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health
    Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität)

  • Henning Tiemeier

    (Department of Psychiatry Erasmus Medical Center)

  • Elena Tremoli

    (Università di Milano
    Centro Cardiologico Monzino, IRCCS)

  • Pim van der Harst

    (University Medical Center Groningen, University of Groningen
    University of Groningen, University Medical Center Groningen
    Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute)

  • Henrik Vestergaard

    (The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
    Steno Diabetes Center)

  • Peter Vollenweider

    (Internal Medicine, Lausanne university hospital (CHUV))

  • Nicholas J. Wareham

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science)

  • David R. Weir

    (Survey Research Center, Institute for Social Research, University of Michigan)

  • John B. Whitfield

    (Genetic Epidemiology, QIMR Berghofer Medical Research Institute)

  • James F. Wilson

    (MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
    Usher Institute for Population Health Sciences and Informatics, The University of Edinburgh)

  • Jessica Tyrrell

    (Genetics of Complex Traits, University of Exeter Medical School, RILD Building University of Exeter
    European Centre for Environment and Human Health, University of Exeter Medical School, The Knowledge Spa)

  • Timothy M. Frayling

    (Genetics of Complex Traits, University of Exeter Medical School, University of Exeter)

  • Inês Barroso

    (Wellcome Trust Sanger Institute
    NIHR Cambridge Biomedical Research Centre, Level 4, Institute of Metabolic Science Box 289 Addenbrooke’s Hospital
    University of Cambridge Metabolic Research Laboratories, Level 4, Institute of Metabolic Science Box 289 Addenbrooke’s Hospital)

  • Michael Boehnke

    (University of Michigan)

  • Panagiotis Deloukas

    (William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
    Wellcome Trust Sanger Institute
    Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University)

  • Caroline S. Fox

    (NHLBI Framingham Heart Study)

  • Joel N. Hirschhorn

    (Boston Children's Hospital
    Broad Institute of Harvard and MIT
    Harvard Medical School)

  • David J. Hunter

    (Harvard T.H. Chan School of Public Health
    Broad Institute of Harvard and MIT
    Harvard T.H. Chan School of Public Health
    Brigham and Women’s Hospital and Harvard Medical School)

  • Tim D. Spector

    (King’s College London)

  • David P. Strachan

    (Population Health Research Institute, St. George's, University of London
    St George's, University of London)

  • Cornelia M. van Duijn

    (Genetic Epidemiology Unit, Erasmus University Medical Center
    Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)
    Center for Medical Systems Biology)

  • Iris M. Heid

    (Institute of Epidemiology and Preventive Medicine, University of Regensburg
    Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health)

  • Karen L. Mohlke

    (University of North Carolina)

  • Jonathan Marchini

    (University of Oxford)

  • Ruth J. F. Loos

    (The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
    The Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai
    MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science
    Mount Sinai School of Medicine)

  • Tuomas O. Kilpeläinen

    (The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
    MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science
    The Icahn School of Medicine at Mount Sinai)

  • Ching-Ti Liu

    (Boston University School of Public Health)

  • Ingrid B. Borecki

    (Washington University School of Medicine)

  • Kari E. North

    (University of North Carolina)

  • L Adrienne Cupples

    (Boston University School of Public Health
    NHLBI Framingham Heart Study)

Abstract

Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution.

Suggested Citation

  • Anne E. Justice & Thomas W. Winkler & Mary F. Feitosa & Misa Graff & Virginia A. Fisher & Kristin Young & Llilda Barata & Xuan Deng & Jacek Czajkowski & David Hadley & Julius S. Ngwa & Tarunveer S. Ah, 2017. "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits," Nature Communications, Nature, vol. 8(1), pages 1-19, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14977
    DOI: 10.1038/ncomms14977
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    Cited by:

    1. Dmitrii Borisevich & Theresia M Schnurr & Line Engelbrechtsen & Alexander Rakitko & Lars Ängquist & Valery Ilinsky & Mette Aadahl & Niels Grarup & Oluf Pedersen & Thorkild I A Sørensen & Torben Hansen, 2021. "Non-linear interaction between physical activity and polygenic risk score of body mass index in Danish and Russian populations," PLOS ONE, Public Library of Science, vol. 16(10), pages 1-16, October.

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