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Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity

Author

Listed:
  • Koenraad Philippaert

    (Laboratory of Ion Channel Research, KU Leuven
    TRP Research Platform Leuven (TRPLe), KU Leuven)

  • Andy Pironet

    (Laboratory of Ion Channel Research, KU Leuven
    TRP Research Platform Leuven (TRPLe), KU Leuven)

  • Margot Mesuere

    (Laboratory of Ion Channel Research, KU Leuven
    TRP Research Platform Leuven (TRPLe), KU Leuven)

  • William Sones

    (Oxford Centre for Diabetes, Endocrinology and Metabolism)

  • Laura Vermeiren

    (Laboratory of Ion Channel Research, KU Leuven
    TRP Research Platform Leuven (TRPLe), KU Leuven)

  • Sara Kerselaers

    (Laboratory of Ion Channel Research, KU Leuven
    TRP Research Platform Leuven (TRPLe), KU Leuven)

  • Sílvia Pinto

    (Laboratory of Ion Channel Research, KU Leuven
    TRP Research Platform Leuven (TRPLe), KU Leuven)

  • Andrei Segal

    (Laboratory of Ion Channel Research, KU Leuven
    TRP Research Platform Leuven (TRPLe), KU Leuven)

  • Nancy Antoine

    (Pôle d'endocrinologie, diabète et nutrition, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain)

  • Conny Gysemans

    (Clinical and Experimental Endocrinology, KU Leuven)

  • Jos Laureys

    (Clinical and Experimental Endocrinology, KU Leuven)

  • Katleen Lemaire

    (Gene Expression Unit, KU Leuven)

  • Patrick Gilon

    (Pôle d'endocrinologie, diabète et nutrition, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain)

  • Eva Cuypers

    (Toxicology and Pharmacology, KU Leuven)

  • Jan Tytgat

    (Toxicology and Pharmacology, KU Leuven)

  • Chantal Mathieu

    (Clinical and Experimental Endocrinology, KU Leuven)

  • Frans Schuit

    (Gene Expression Unit, KU Leuven)

  • Patrik Rorsman

    (Oxford Centre for Diabetes, Endocrinology and Metabolism)

  • Karel Talavera

    (Laboratory of Ion Channel Research, KU Leuven
    TRP Research Platform Leuven (TRPLe), KU Leuven)

  • Thomas Voets

    (Laboratory of Ion Channel Research, KU Leuven
    TRP Research Platform Leuven (TRPLe), KU Leuven)

  • Rudi Vennekens

    (Laboratory of Ion Channel Research, KU Leuven
    TRP Research Platform Leuven (TRPLe), KU Leuven)

Abstract

Steviol glycosides (SGs), such as stevioside and rebaudioside A, are natural, non-caloric sweet-tasting organic molecules, present in extracts of the scrub plant Stevia rebaudiana, which are widely used as sweeteners in consumer foods and beverages. TRPM5 is a Ca2+-activated cation channel expressed in type II taste receptor cells and pancreatic β-cells. Here we show that stevioside, rebaudioside A and their aglycon steviol potentiate the activity of TRPM5. We find that SGs potentiate perception of bitter, sweet and umami taste, and enhance glucose-induced insulin secretion in a Trpm5-dependent manner. Daily consumption of stevioside prevents development of high-fat-diet-induced diabetic hyperglycaemia in wild-type mice, but not in Trpm5−/− mice. These results elucidate a molecular mechanism of action of SGs and identify TRPM5 as a potential target to prevent and treat type 2 diabetes.

Suggested Citation

  • Koenraad Philippaert & Andy Pironet & Margot Mesuere & William Sones & Laura Vermeiren & Sara Kerselaers & Sílvia Pinto & Andrei Segal & Nancy Antoine & Conny Gysemans & Jos Laureys & Katleen Lemaire , 2017. "Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity," Nature Communications, Nature, vol. 8(1), pages 1-16, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14733
    DOI: 10.1038/ncomms14733
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    Cited by:

    1. Qiang Yu & Igor Gamayun & Philipp Wartenberg & Qian Zhang & Sen Qiao & Soumya Kusumakshi & Sarah Candlish & Viktoria Götz & Shuping Wen & Debajyoti Das & Amanda Wyatt & Vanessa Wahl & Fabien Ectors & , 2023. "Bitter taste cells in the ventricular walls of the murine brain regulate glucose homeostasis," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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