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Global metabolic rewiring for improved CO2 fixation and chemical production in cyanobacteria

Author

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  • Masahiro Kanno

    (University of California
    Asahi Kasei Corporation)

  • Austin L. Carroll

    (University of California)

  • Shota Atsumi

    (University of California)

Abstract

Cyanobacteria have attracted much attention as hosts to recycle CO2 into valuable chemicals. Although cyanobacteria have been engineered to produce various compounds, production efficiencies are too low for commercialization. Here we engineer the carbon metabolism of Synechococcus elongatus PCC 7942 to improve glucose utilization, enhance CO2 fixation and increase chemical production. We introduce modifications in glycolytic pathways and the Calvin Benson cycle to increase carbon flux and redirect it towards carbon fixation. The engineered strain efficiently uses both CO2 and glucose, and produces 12.6 g l−1 of 2,3-butanediol with a rate of 1.1 g l−1 d−1 under continuous light conditions. Removal of native regulation enables carbon fixation and 2,3-butanediol production in the absence of light. This represents a significant step towards industrial viability and an excellent example of carbon metabolism plasticity.

Suggested Citation

  • Masahiro Kanno & Austin L. Carroll & Shota Atsumi, 2017. "Global metabolic rewiring for improved CO2 fixation and chemical production in cyanobacteria," Nature Communications, Nature, vol. 8(1), pages 1-11, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14724
    DOI: 10.1038/ncomms14724
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    Cited by:

    1. Feng Gao & Guangyu Liu & Aobo Chen & Yangguang Hu & Huihui Wang & Jiangyuan Pan & Jinglei Feng & Hongwei Zhang & Yujie Wang & Yuanzeng Min & Chao Gao & Yujie Xiong, 2023. "Artificial photosynthetic cells with biotic–abiotic hybrid energy modules for customized CO2 conversion," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. Yang-le Gao & Jason E. Cournoyer & Bidhan C. De & Catherine L. Wallace & Alexander V. Ulanov & Michael R. La Frano & Angad P. Mehta, 2024. "Introducing carbon assimilation in yeasts using photosynthetic directed endosymbiosis," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    3. Shanshan Zhang & Jiahui Sun & Dandan Feng & Huili Sun & Jinyu Cui & Xuexia Zeng & Yannan Wu & Guodong Luan & Xuefeng Lu, 2023. "Unlocking the potentials of cyanobacterial photosynthesis for directly converting carbon dioxide into glucose," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    4. Bhatia, Shashi Kant & Bhatia, Ravi Kant & Jeon, Jong-Min & Kumar, Gopalakrishnan & Yang, Yung-Hun, 2019. "Carbon dioxide capture and bioenergy production using biological system – A review," Renewable and Sustainable Energy Reviews, Elsevier, vol. 110(C), pages 143-158.

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