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In vivo gastrointestinal drug-release monitoring through second near-infrared window fluorescent bioimaging with orally delivered microcarriers

Author

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  • Rui Wang

    (Laboratory of Advanced Materials, Collaborative Innovation Center of Chemistry for Energy Materials, State Key Laboratory of Molecular Engineering of Polymers, Fudan University)

  • Lei Zhou

    (Laboratory of Advanced Materials, Collaborative Innovation Center of Chemistry for Energy Materials, State Key Laboratory of Molecular Engineering of Polymers, Fudan University)

  • Wenxing Wang

    (Laboratory of Advanced Materials, Collaborative Innovation Center of Chemistry for Energy Materials, State Key Laboratory of Molecular Engineering of Polymers, Fudan University)

  • Xiaomin Li

    (Laboratory of Advanced Materials, Collaborative Innovation Center of Chemistry for Energy Materials, State Key Laboratory of Molecular Engineering of Polymers, Fudan University)

  • Fan Zhang

    (Laboratory of Advanced Materials, Collaborative Innovation Center of Chemistry for Energy Materials, State Key Laboratory of Molecular Engineering of Polymers, Fudan University)

Abstract

Non-invasive monitoring of gastrointestinal drug release in vivo is extremely challenging because of the limited spatial resolution and long scanning time of existing bioimaging modalities, such as X-ray radiation and magnetic resonance. Here, we report a novel microcarrier that can retain drugs and withstand the harsh conditions of gastrointestinal tract. Significantly, we can track the microcarrier fate and semi-quantitatively monitor the content of drug released in vivo in real time by measuring the fluorescence signals in the second near-infrared window of lanthanide-based downconversion nanoparticles with an absorption competition-induced emission bioimaging system. The microcarriers show a prolonged residence time of up to 72 h in the gastrointestinal tract, releasing up to 62% of their content. Moreover, minimal deposition of the microcarriers is found in non-target organs, such as the liver, spleen and kidney. These findings provide novel insights for the development of therapeutic and bioimaging strategies of orally administered drugs.

Suggested Citation

  • Rui Wang & Lei Zhou & Wenxing Wang & Xiaomin Li & Fan Zhang, 2017. "In vivo gastrointestinal drug-release monitoring through second near-infrared window fluorescent bioimaging with orally delivered microcarriers," Nature Communications, Nature, vol. 8(1), pages 1-12, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14702
    DOI: 10.1038/ncomms14702
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    Cited by:

    1. Aiyan Ji & Hongyue Lou & Chunrong Qu & Wanglong Lu & Yifan Hao & Jiafeng Li & Yuyang Wu & Tonghang Chang & Hao Chen & Zhen Cheng, 2022. "Acceptor engineering for NIR-II dyes with high photochemical and biomedical performance," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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