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Photothermally triggered actuation of hybrid materials as a new platform for in vitro cell manipulation

Author

Listed:
  • Amy Sutton

    (Harvard University)

  • Tanya Shirman

    (John A. Paulson School of Engineering and Applied Sciences, Harvard University
    Wyss Institute for Biologically Inspired Engineering, Harvard University)

  • Jaakko V. I. Timonen

    (John A. Paulson School of Engineering and Applied Sciences, Harvard University
    Aalto University)

  • Grant T England

    (John A. Paulson School of Engineering and Applied Sciences, Harvard University)

  • Philseok Kim

    (Wyss Institute for Biologically Inspired Engineering, Harvard University)

  • Mathias Kolle

    (Department of Mechanical Engineering Massachusetts Institute of Technology)

  • Thomas Ferrante

    (Wyss Institute for Biologically Inspired Engineering, Harvard University)

  • Lauren D Zarzar

    (Harvard University
    The Pennsylvania State University)

  • Elizabeth Strong

    (Harvard College, Harvard University)

  • Joanna Aizenberg

    (Harvard University
    John A. Paulson School of Engineering and Applied Sciences, Harvard University
    Wyss Institute for Biologically Inspired Engineering, Harvard University)

Abstract

Mechanical forces in the cell’s natural environment have a crucial impact on growth, differentiation and behaviour. Few areas of biology can be understood without taking into account how both individual cells and cell networks sense and transduce physical stresses. However, the field is currently held back by the limitations of the available methods to apply physiologically relevant stress profiles on cells, particularly with sub-cellular resolution, in controlled in vitro experiments. Here we report a new type of active cell culture material that allows highly localized, directional and reversible deformation of the cell growth substrate, with control at scales ranging from the entire surface to the subcellular, and response times on the order of seconds. These capabilities are not matched by any other method, and this versatile material has the potential to bridge the performance gap between the existing single cell micro-manipulation and 2D cell sheet mechanical stimulation techniques.

Suggested Citation

  • Amy Sutton & Tanya Shirman & Jaakko V. I. Timonen & Grant T England & Philseok Kim & Mathias Kolle & Thomas Ferrante & Lauren D Zarzar & Elizabeth Strong & Joanna Aizenberg, 2017. "Photothermally triggered actuation of hybrid materials as a new platform for in vitro cell manipulation," Nature Communications, Nature, vol. 8(1), pages 1-13, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14700
    DOI: 10.1038/ncomms14700
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    Cited by:

    1. Thomas B. H. Schroeder & Joanna Aizenberg, 2022. "Patterned crystal growth and heat wave generation in hydrogels," Nature Communications, Nature, vol. 13(1), pages 1-8, December.

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