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Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness

Author

Listed:
  • Stefanie Heilmann-Heimbach

    (Institute of Human Genetics, University of Bonn
    Life & Brain Center, University of Bonn)

  • Christine Herold

    (German Center for Neurodegenerative Disorders)

  • Lara M. Hochfeld

    (Institute of Human Genetics, University of Bonn
    Life & Brain Center, University of Bonn)

  • Axel M. Hillmer

    (Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore
    TRON-Translational Oncology at the University Medical Center of Johannes Gutenberg University)

  • Dale R. Nyholt

    (Institute of Health and Biomedical Innovation, Queensland University of Technology)

  • Julian Hecker

    (Institute of Genomic Mathematics, University of Bonn)

  • Asif Javed

    (Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore)

  • Elaine G. Y. Chew

    (Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore)

  • Sonali Pechlivanis

    (Institute of Medical Informatics, Biometry and Epidemiology, Medical Faculty, University of Duisburg-Essen)

  • Dmitriy Drichel

    (Cologne Center for Genomics, University of Cologne)

  • Xiu Ting Heng

    (Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore)

  • Ricardo C. -H. del Rosario

    (Computational and Systems Biology, Genome Institute of Singapore)

  • Heide L. Fier

    (Institute of Genomic Mathematics, University of Bonn
    Harvard School T.H. Chan of Public Health)

  • Ralf Paus

    (Dermatology Research Centre, Institute of Inflammation and Repair, University of Manchester)

  • Rico Rueedi

    (University of Lausanne
    Swiss Institute of Bioinformatics)

  • Tessel E. Galesloot

    (Radboud Institute for Health Sciences, Radboud University Medical Center)

  • Susanne Moebus

    (Institute of Medical Informatics, Biometry and Epidemiology, Medical Faculty, University of Duisburg-Essen)

  • Thomas Anhalt

    (Institute of Human Genetics, University of Bonn
    Life & Brain Center, University of Bonn)

  • Shyam Prabhakar

    (Computational and Systems Biology, Genome Institute of Singapore)

  • Rui Li

    (Centre for Clinical Epidemiology, Genetics and Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University)

  • Stavroula Kanoni

    (William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London)

  • George Papanikolaou

    (School of Health Sciences and Education, Harokopio University)

  • Zoltán Kutalik

    (Swiss Institute of Bioinformatics
    Institute of Social and Preventive Medicine, University Hospital of Lausanne)

  • Panos Deloukas

    (William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
    Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University)

  • Michael P. Philpott

    (Centre for Cell Biology and Cutaneous Research Barts and The London School of Medicine and Dentistry, Queen Mary University of London)

  • Gérard Waeber

    (Lausanne University Hospital (CHUV))

  • Tim D. Spector

    (King's College London)

  • Peter Vollenweider

    (Lausanne University Hospital (CHUV))

  • Lambertus A. L. M. Kiemeney

    (Radboud Institute for Health Sciences, Radboud University Medical Center)

  • George Dedoussis

    (School of Health Sciences and Education, Harokopio University)

  • J. Brent Richards

    (Centre for Clinical Epidemiology, Genetics and Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University
    King's College London)

  • Michael Nothnagel

    (Cologne Center for Genomics, University of Cologne)

  • Nicholas G. Martin

    (QIMR Berghofer Medical Research Institute)

  • Tim Becker

    (Institute for Community Medicine, Ernst Moritz Arndt University Greifswald)

  • David A. Hinds

    (23andMe Inc.)

  • Markus M. Nöthen

    (Institute of Human Genetics, University of Bonn
    Life & Brain Center, University of Bonn)

Abstract

Male-pattern baldness (MPB) is a common and highly heritable trait characterized by androgen-dependent, progressive hair loss from the scalp. Here, we carry out the largest GWAS meta-analysis of MPB to date, comprising 10,846 early-onset cases and 11,672 controls from eight independent cohorts. We identify 63 MPB-associated loci (P

Suggested Citation

  • Stefanie Heilmann-Heimbach & Christine Herold & Lara M. Hochfeld & Axel M. Hillmer & Dale R. Nyholt & Julian Hecker & Asif Javed & Elaine G. Y. Chew & Sonali Pechlivanis & Dmitriy Drichel & Xiu Ting H, 2017. "Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness," Nature Communications, Nature, vol. 8(1), pages 1-8, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14694
    DOI: 10.1038/ncomms14694
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    Cited by:

    1. Sabrina Katrin Henne & Rana Aldisi & Sugirthan Sivalingam & Lara Maleen Hochfeld & Oleg Borisov & Peter Michael Krawitz & Carlo Maj & Markus Maria Nöthen & Stefanie Heilmann-Heimbach, 2023. "Analysis of 72,469 UK Biobank exomes links rare variants to male-pattern hair loss," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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