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The role of alternative polyadenylation in the antiviral innate immune response

Author

Listed:
  • Xin Jia

    (State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University)

  • Shaochun Yuan

    (State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University)

  • Yao Wang

    (State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University)

  • Yonggui Fu

    (State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University)

  • Yong Ge

    (State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University)

  • Yutong Ge

    (State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University)

  • Xihong Lan

    (State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University)

  • Yuchao Feng

    (State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University)

  • Feifei Qiu

    (State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University)

  • Peiyi Li

    (State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University)

  • Shangwu Chen

    (State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University)

  • Anlong Xu

    (State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University
    School of Life Science, Beijing University of Chinese Medicine)

Abstract

Alternative polyadenylation (APA) is an important regulatory mechanism of gene functions in many biological processes. However, the extent of 3′ UTR variation and the function of APA during the innate antiviral immune response are unclear. Here, we show genome-wide poly(A) sites switch and average 3′ UTR length shortens gradually in response to vesicular stomatitis virus (VSV) infection in macrophages. Genes with APA and mRNA abundance change are enriched in immune-related categories such as the Toll-like receptor, RIG-I-like receptor, JAK-STAT and apoptosis-related signalling pathways. The expression of 3′ processing factors is down-regulated upon VSV infection. When the core 3′ processing factors are knocked down, viral replication is affected. Thus, our study reports the annotation of genes with APA in antiviral immunity and highlights the roles of 3′ processing factors on 3′ UTR variation upon viral infection.

Suggested Citation

  • Xin Jia & Shaochun Yuan & Yao Wang & Yonggui Fu & Yong Ge & Yutong Ge & Xihong Lan & Yuchao Feng & Feifei Qiu & Peiyi Li & Shangwu Chen & Anlong Xu, 2017. "The role of alternative polyadenylation in the antiviral innate immune response," Nature Communications, Nature, vol. 8(1), pages 1-12, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14605
    DOI: 10.1038/ncomms14605
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    Cited by:

    1. Lei Li & Xuelian Ma & Ya Cui & Maxime Rotival & Wenyan Chen & Xudong Zou & Ruofan Ding & Yangmei Qin & Qixuan Wang & Lluis Quintana-Murci & Wei Li, 2023. "Immune-response 3′UTR alternative polyadenylation quantitative trait loci contribute to variation in human complex traits and diseases," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Valter Bergant & Daniel Schnepf & Niklas Andrade Krätzig & Philipp Hubel & Christian Urban & Thomas Engleitner & Ronald Dijkman & Bernhard Ryffel & Katja Steiger & Percy A. Knolle & Georg Kochs & Rola, 2023. "mRNA 3’UTR lengthening by alternative polyadenylation attenuates inflammatory responses and correlates with virulence of Influenza A virus," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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