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Circadian deep sequencing reveals stress-response genes that adopt robust rhythmic expression during aging

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  • Rachael C. Kuintzle

    (2011 Agriculture & Life Sciences Building, Oregon State University
    Present address: California Institute of Technology, Division of Chemistry and Chemical Engineering, 1200 East California Boulevard, Pasadena, California 91125, USA)

  • Eileen S. Chow

    (3029 Cordley Hall, Oregon State University)

  • Tara N. Westby

    (3029 Cordley Hall, Oregon State University)

  • Barbara O. Gvakharia

    (3029 Cordley Hall, Oregon State University)

  • Jadwiga M. Giebultowicz

    (3029 Cordley Hall, Oregon State University)

  • David A Hendrix

    (2011 Agriculture & Life Sciences Building, Oregon State University
    School of Electrical Engineering and Computer Science, 1148 Kelley Engineering Center, Oregon State University)

Abstract

Disruption of the circadian clock, which directs rhythmic expression of numerous output genes, accelerates aging. To enquire how the circadian system protects aging organisms, here we compare circadian transcriptomes in heads of young and old Drosophila melanogaster. The core clock and most output genes remained robustly rhythmic in old flies, while others lost rhythmicity with age, resulting in constitutive over- or under-expression. Unexpectedly, we identify a subset of genes that adopted increased or de novo rhythmicity during aging, enriched for stress-response functions. These genes, termed late-life cyclers, were also rhythmically induced in young flies by constant exposure to exogenous oxidative stress, and this upregulation is CLOCK-dependent. We also identify age-onset rhythmicity in several putative primary piRNA transcripts overlapping antisense transposons. Our results suggest that, as organisms age, the circadian system shifts greater regulatory priority to the mitigation of accumulating cellular stress.

Suggested Citation

  • Rachael C. Kuintzle & Eileen S. Chow & Tara N. Westby & Barbara O. Gvakharia & Jadwiga M. Giebultowicz & David A Hendrix, 2017. "Circadian deep sequencing reveals stress-response genes that adopt robust rhythmic expression during aging," Nature Communications, Nature, vol. 8(1), pages 1-10, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14529
    DOI: 10.1038/ncomms14529
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    Cited by:

    1. Brian A. Hodge & Geoffrey T. Meyerhof & Subhash D. Katewa & Ting Lian & Charles Lau & Sudipta Bar & Nicole Y. Leung & Menglin Li & David Li-Kroeger & Simon Melov & Birgit Schilling & Craig Montell & P, 2022. "Dietary restriction and the transcription factor clock delay eye aging to extend lifespan in Drosophila Melanogaster," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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