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NMDA-receptor-dependent plasticity in the bed nucleus of the stria terminalis triggers long-term anxiolysis

Author

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  • Christelle Glangetas

    (Université de Bordeaux, Interdisciplinary Institute for Neuroscience
    Centre National de la Recherche Scientifique, Interdisciplinary Institute for Neuroscience)

  • Léma Massi

    (Friedrich Miescher Institute for Biomedical Research)

  • Giulia R. Fois

    (Centre National de la Recherche Scientifique, Neurodegeneratives Diseases Institute)

  • Marion Jalabert

    (Université de la Méditerranée UMR S901
    INMED)

  • Delphine Girard

    (Université de Bordeaux, Interdisciplinary Institute for Neuroscience
    Centre National de la Recherche Scientifique, Interdisciplinary Institute for Neuroscience
    Centre National de la Recherche Scientifique, Neurodegeneratives Diseases Institute)

  • Marco Diana

    (‘G. Minardi’ Cognitive Neuroscience Laboratory, University of Sassari)

  • Keisuke Yonehara

    (Friedrich Miescher Institute for Biomedical Research)

  • Botond Roska

    (Friedrich Miescher Institute for Biomedical Research)

  • Chun Xu

    (Friedrich Miescher Institute for Biomedical Research)

  • Andreas Lüthi

    (Friedrich Miescher Institute for Biomedical Research)

  • Stéphanie Caille

    (Université de Bordeaux, Institut de Neurosciences Cognitives et Intégrative d’Aquitaine, BP31
    Centre National de la Recherche Scientifique, UMR 5287-Institut de Neurosciences Cognitives et Intégrative d’Aquitaine)

  • François Georges

    (Université de Bordeaux, Interdisciplinary Institute for Neuroscience
    Centre National de la Recherche Scientifique, Interdisciplinary Institute for Neuroscience
    Centre National de la Recherche Scientifique, Neurodegeneratives Diseases Institute)

Abstract

Anxiety is controlled by multiple neuronal circuits that share robust and reciprocal connections with the bed nucleus of the stria terminalis (BNST), a key structure controlling negative emotional states. However, it remains unknown how the BNST integrates diverse inputs to modulate anxiety. In this study, we evaluated the contribution of infralimbic cortex (ILCx) and ventral subiculum/CA1 (vSUB/CA1) inputs in regulating BNST activity at the single-cell level. Using trans-synaptic tracing from single-electroporated neurons and in vivo recordings, we show that vSUB/CA1 stimulation promotes opposite forms of in vivo plasticity at the single-cell level in the anteromedial part of the BNST (amBNST). We find that an NMDA-receptor-dependent homosynaptic long-term potentiation is instrumental for anxiolysis. These findings suggest that the vSUB/CA1-driven LTP in the amBNST is involved in eliciting an appropriate response to anxiogenic context and dysfunction of this compensatory mechanism may underlie pathologic anxiety states.

Suggested Citation

  • Christelle Glangetas & Léma Massi & Giulia R. Fois & Marion Jalabert & Delphine Girard & Marco Diana & Keisuke Yonehara & Botond Roska & Chun Xu & Andreas Lüthi & Stéphanie Caille & François Georges, 2017. "NMDA-receptor-dependent plasticity in the bed nucleus of the stria terminalis triggers long-term anxiolysis," Nature Communications, Nature, vol. 8(1), pages 1-7, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14456
    DOI: 10.1038/ncomms14456
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    Cited by:

    1. Christelle Glangetas & Adriane Guillaumin & Elodie Ladevèze & Anaelle Braine & Manon Gauthier & Léa Bonamy & Evelyne Doudnikoff & Thibault Dhellemmes & Marc Landry & Erwan Bézard & Stephanie Caille & , 2024. "A population of Insula neurons encodes for social preference only after acute social isolation in mice," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Ren-Wen Han & Zi-Yi Zhang & Chen Jiao & Ze-Yu Hu & Bing-Xing Pan, 2024. "Synergism between two BLA-to-BNST pathways for appropriate expression of anxiety-like behaviors in male mice," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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