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Cationic amino acid transporters play key roles in the survival and transmission of apicomplexan parasites

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  • Esther Rajendran

    (Research School of Biology, Australian National University)

  • Sanduni V. Hapuarachchi

    (Research School of Biology, Australian National University)

  • Catherine M. Miller

    (College of Public Health, Medical and Veterinary Sciences, James Cook University)

  • Stephen J. Fairweather

    (Research School of Biology, Australian National University)

  • Yeping Cai

    (John Curtin School of Medical Research, Australian National University)

  • Nicholas C. Smith

    (Queensland Tropical Health Alliance Research Laboratory, Australian Institute of Tropical Health and Medicine, James Cook University)

  • Ian A. Cockburn

    (John Curtin School of Medical Research, Australian National University)

  • Stefan Bröer

    (Research School of Biology, Australian National University)

  • Kiaran Kirk

    (Research School of Biology, Australian National University)

  • Giel G. van Dooren

    (Research School of Biology, Australian National University)

Abstract

Apicomplexans are obligate intracellular parasites that scavenge essential nutrients from their hosts via transporter proteins on their plasma membrane. The identities of the transporters that mediate amino acid uptake into apicomplexans are unknown. Here we demonstrate that members of an apicomplexan-specific protein family—the Novel Putative Transporters (NPTs)—play key roles in the uptake of cationic amino acids. We show that an NPT from Toxoplasma gondii (TgNPT1) is a selective arginine transporter that is essential for parasite survival and virulence. We also demonstrate that a homologue of TgNPT1 from the malaria parasite Plasmodium berghei (PbNPT1), shown previously to be essential for the sexual gametocyte stage of the parasite, is a cationic amino acid transporter. This reveals a role for cationic amino acid scavenging in gametocyte biology. Our study demonstrates a critical role for amino acid transporters in the survival, virulence and life cycle progression of these parasites.

Suggested Citation

  • Esther Rajendran & Sanduni V. Hapuarachchi & Catherine M. Miller & Stephen J. Fairweather & Yeping Cai & Nicholas C. Smith & Ian A. Cockburn & Stefan Bröer & Kiaran Kirk & Giel G. van Dooren, 2017. "Cationic amino acid transporters play key roles in the survival and transmission of apicomplexan parasites," Nature Communications, Nature, vol. 8(1), pages 1-13, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14455
    DOI: 10.1038/ncomms14455
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    Cited by:

    1. Wenyan Wan & Hui Dong & De-Hua Lai & Jiong Yang & Kai He & Xiaoyan Tang & Qun Liu & Geoff Hide & Xing-Quan Zhu & L. David Sibley & Zhao-Rong Lun & Shaojun Long, 2023. "The Toxoplasma micropore mediates endocytosis for selective nutrient salvage from host cell compartments," Nature Communications, Nature, vol. 14(1), pages 1-21, December.

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