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Dynamics of auditory cortical activity during behavioural engagement and auditory perception

Author

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  • Ioana Carcea

    (Neuroscience and Physiology, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Center for Neural Science, New York University)

  • Michele N. Insanally

    (Neuroscience and Physiology, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Center for Neural Science, New York University)

  • Robert C. Froemke

    (Neuroscience and Physiology, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Center for Neural Science, New York University)

Abstract

Behavioural engagement can enhance sensory perception. However, the neuronal mechanisms by which behavioural states affect stimulus perception remain poorly understood. Here we record from single units in auditory cortex of rats performing a self-initiated go/no-go auditory task. Self-initiation transforms cortical tuning curves and bidirectionally modulates stimulus-evoked activity patterns and improves auditory detection and recognition. Trial self-initiation decreases the rate of spontaneous activity in the majority of recorded cells. Optogenetic disruption of cortical activity before and during tone presentation shows that these changes in evoked and spontaneous activity are important for sound perception. Thus, behavioural engagement can prepare cortical circuits for sensory processing by dynamically changing sound representation and by controlling the pattern of spontaneous activity.

Suggested Citation

  • Ioana Carcea & Michele N. Insanally & Robert C. Froemke, 2017. "Dynamics of auditory cortical activity during behavioural engagement and auditory perception," Nature Communications, Nature, vol. 8(1), pages 1-12, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14412
    DOI: 10.1038/ncomms14412
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    Cited by:

    1. Albert M. Barth & Marta Jelitai & Maria Flora Vasarhelyi-Nagy & Viktor Varga, 2023. "Aversive stimulus-tuned responses in the CA1 of the dorsal hippocampus," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Michele N. Insanally & Badr F. Albanna & Jade Toth & Brian DePasquale & Saba Shokat Fadaei & Trisha Gupta & Olivia Lombardi & Kishore Kuchibhotla & Kanaka Rajan & Robert C. Froemke, 2024. "Contributions of cortical neuron firing patterns, synaptic connectivity, and plasticity to task performance," Nature Communications, Nature, vol. 15(1), pages 1-21, December.

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