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Neutrophils dominate the immune cell composition in non-small cell lung cancer

Author

Listed:
  • Julia Kargl

    (Clinical Research Division
    Institute of Experimental and Clinical Pharmacology, Medical University of Graz)

  • Stephanie E. Busch

    (Clinical Research Division)

  • Grace H. Y. Yang

    (Clinical Research Division)

  • Kyoung-Hee Kim

    (Clinical Research Division)

  • Mark L. Hanke

    (Clinical Research Division)

  • Heather E. Metz

    (Clinical Research Division)

  • Jesse J. Hubbard

    (Clinical Research Division)

  • Sylvia M. Lee

    (Clinical Research Division)

  • David K. Madtes

    (Clinical Research Division
    University of Washington)

  • Martin W. McIntosh

    (Fred Hutchinson Cancer Research Center)

  • A. McGarry Houghton

    (Clinical Research Division
    University of Washington
    Human Biology Division)

Abstract

The response rate to immune checkpoint inhibitor therapy for non-small-cell lung cancer (NSCLC) is just 20%. To improve this figure, several early phase clinical trials combining novel immunotherapeutics with immune checkpoint blockade have been initiated. Unfortunately, these trials have been designed without a strong foundational knowledge of the immune landscape present in NSCLC. Here, we use a flow cytometry panel capable of measuring 51 immune cell populations to comprehensively identify the immune cell composition and function in NSCLC. The results show that the immune cell composition is fundamentally different in lung adenocarcinoma as compared with lung squamous cell carcinoma, and that neutrophils are the most prevalent immune cell type. Using T-cell receptor-β sequencing and tumour reactivity assays, we predict that tumour reactive T cells are frequently present in NSCLC. These results should help to guide the design of clinical trials and the direction of future research in this area.

Suggested Citation

  • Julia Kargl & Stephanie E. Busch & Grace H. Y. Yang & Kyoung-Hee Kim & Mark L. Hanke & Heather E. Metz & Jesse J. Hubbard & Sylvia M. Lee & David K. Madtes & Martin W. McIntosh & A. McGarry Houghton, 2017. "Neutrophils dominate the immune cell composition in non-small cell lung cancer," Nature Communications, Nature, vol. 8(1), pages 1-11, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14381
    DOI: 10.1038/ncomms14381
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