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Accelerating the search for the missing proteins in the human proteome

Author

Listed:
  • Mark S. Baker

    (Faculty of Medicine & Health Sciences, Macquarie University)

  • Seong Beom Ahn

    (Faculty of Medicine & Health Sciences, Macquarie University)

  • Abidali Mohamedali

    (Faculty of Medicine & Health Sciences, Macquarie University
    Macquarie University)

  • Mohammad T. Islam

    (Macquarie University)

  • David Cantor

    (Faculty of Medicine & Health Sciences, Macquarie University)

  • Peter D. Verhaert

    (Antwerp University, Antwerpen 2020)

  • Susan Fanayan

    (Faculty of Medicine & Health Sciences, Macquarie University)

  • Samridhi Sharma

    (Faculty of Medicine & Health Sciences, Macquarie University)

  • Edouard C. Nice

    (Monash University)

  • Mark Connor

    (Faculty of Medicine & Health Sciences, Macquarie University)

  • Shoba Ranganathan

    (Macquarie University)

Abstract

The Human Proteome Project (HPP) aims to discover high-stringency data for all proteins encoded by the human genome. Currently, ∼18% of the proteins in the human proteome (the missing proteins) do not have high-stringency evidence (for example, mass spectrometry) confirming their existence, while much additional information is available about many of these missing proteins. Here, we present MissingProteinPedia as a community resource to accelerate the discovery and understanding of these missing proteins.

Suggested Citation

  • Mark S. Baker & Seong Beom Ahn & Abidali Mohamedali & Mohammad T. Islam & David Cantor & Peter D. Verhaert & Susan Fanayan & Samridhi Sharma & Edouard C. Nice & Mark Connor & Shoba Ranganathan, 2017. "Accelerating the search for the missing proteins in the human proteome," Nature Communications, Nature, vol. 8(1), pages 1-13, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14271
    DOI: 10.1038/ncomms14271
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    Cited by:

    1. Bo Wen & Bing Zhang, 2023. "PepQuery2 democratizes public MS proteomics data for rapid peptide searching," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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