IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v8y2017i1d10.1038_ncomms14238.html
   My bibliography  Save this article

Clustering of 770,000 genomes reveals post-colonial population structure of North America

Author

Listed:
  • Eunjung Han

    (AncestryDNA)

  • Peter Carbonetto

    (AncestryDNA)

  • Ross E. Curtis

    (AncestryDNA)

  • Yong Wang

    (AncestryDNA)

  • Julie M. Granka

    (AncestryDNA)

  • Jake Byrnes

    (AncestryDNA)

  • Keith Noto

    (AncestryDNA)

  • Amir R. Kermany

    (AncestryDNA)

  • Natalie M. Myres

    (AncestryDNA)

  • Mathew J. Barber

    (AncestryDNA)

  • Kristin A. Rand

    (AncestryDNA)

  • Shiya Song

    (University of Michigan)

  • Theodore Roman

    (School of Computer Science, Carnegie Mellon University)

  • Erin Battat

    (W.E.B. Du Bois Research Institute, Hutchins Center for African and African American Research, Harvard University)

  • Eyal Elyashiv

    (AncestryDNA)

  • Harendra Guturu

    (AncestryDNA)

  • Eurie L. Hong

    (AncestryDNA)

  • Kenneth G. Chahine

    (AncestryDNA)

  • Catherine A. Ball

    (AncestryDNA)

Abstract

Despite strides in characterizing human history from genetic polymorphism data, progress in identifying genetic signatures of recent demography has been limited. Here we identify very recent fine-scale population structure in North America from a network of over 500 million genetic (identity-by-descent, IBD) connections among 770,000 genotyped individuals of US origin. We detect densely connected clusters within the network and annotate these clusters using a database of over 20 million genealogical records. Recent population patterns captured by IBD clustering include immigrants such as Scandinavians and French Canadians; groups with continental admixture such as Puerto Ricans; settlers such as the Amish and Appalachians who experienced geographic or cultural isolation; and broad historical trends, including reduced north-south gene flow. Our results yield a detailed historical portrait of North America after European settlement and support substantial genetic heterogeneity in the United States beyond that uncovered by previous studies.

Suggested Citation

  • Eunjung Han & Peter Carbonetto & Ross E. Curtis & Yong Wang & Julie M. Granka & Jake Byrnes & Keith Noto & Amir R. Kermany & Natalie M. Myres & Mathew J. Barber & Kristin A. Rand & Shiya Song & Theodo, 2017. "Clustering of 770,000 genomes reveals post-colonial population structure of North America," Nature Communications, Nature, vol. 8(1), pages 1-12, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14238
    DOI: 10.1038/ncomms14238
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms14238
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms14238?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Bing Guo & Victor Borda & Roland Laboulaye & Michele D. Spring & Mariusz Wojnarski & Brian A. Vesely & Joana C. Silva & Norman C. Waters & Timothy D. O’Connor & Shannon Takala-Harrison, 2024. "Strong positive selection biases identity-by-descent-based inferences of recent demography and population structure in Plasmodium falciparum," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14238. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.