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Serotonin-dependent kinetics of feeding bursts underlie a graded response to food availability in C. elegans

Author

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  • Kyung Suk Lee

    (Harvard University
    FAS Center for Systems Biology, Harvard University)

  • Shachar Iwanir

    (The University of Chicago)

  • Ronen B. Kopito

    (Harvard University)

  • Monika Scholz

    (The University of Chicago)

  • John A. Calarco

    (FAS Center for Systems Biology, Harvard University)

  • David Biron

    (The University of Chicago
    The Institute for Biophysical Dynamics, The University of Chicago)

  • Erel Levine

    (Harvard University
    FAS Center for Systems Biology, Harvard University)

Abstract

Animals integrate physiological and environmental signals to modulate their food uptake. The nematode C. elegans, whose food uptake consists of pumping bacteria from the environment into the gut, provides excellent opportunities for discovering principles of conserved regulatory mechanisms. Here we show that worms implement a graded feeding response to the concentration of environmental bacteria by modulating a commitment to bursts of fast pumping. Using long-term, high-resolution, longitudinal recordings of feeding dynamics under defined conditions, we find that the frequency and duration of pumping bursts increase and the duration of long pauses diminishes in environments richer in bacteria. The bioamine serotonin is required for food-dependent induction of bursts as well as for maintaining their high rate of pumping through two distinct mechanisms. We identify the differential roles of distinct families of serotonin receptors in this process and propose that regulation of bursts is a conserved mechanism of behaviour and motor control.

Suggested Citation

  • Kyung Suk Lee & Shachar Iwanir & Ronen B. Kopito & Monika Scholz & John A. Calarco & David Biron & Erel Levine, 2017. "Serotonin-dependent kinetics of feeding bursts underlie a graded response to food availability in C. elegans," Nature Communications, Nature, vol. 8(1), pages 1-11, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14221
    DOI: 10.1038/ncomms14221
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    Cited by:

    1. Hillary A. Miller & Shijiao Huang & Elizabeth S. Dean & Megan L. Schaller & Angela M. Tuckowski & Allyson S. Munneke & Safa Beydoun & Scott D. Pletcher & Scott F. Leiser, 2022. "Serotonin and dopamine modulate aging in response to food odor and availability," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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