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Blunted ventral striatal responses to anticipated rewards foreshadow problematic drug use in novelty-seeking adolescents

Author

Listed:
  • Christian Büchel

    (Universitätsklinikum Hamburg Eppendorf
    Stanford University)

  • Jan Peters

    (Universitätsklinikum Hamburg Eppendorf)

  • Tobias Banaschewski

    (Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University)

  • Arun L. W. Bokde

    (Institute of Neuroscience and Discipline of Psychiatry, School of Medicine, Trinity College Dublin)

  • Uli Bromberg

    (Universitätsklinikum Hamburg Eppendorf)

  • Patricia J. Conrod

    (Institute of Psychiatry, King’s College London
    Université de Montreal, CHU Ste Justine Hospital)

  • Herta Flor

    (Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University)

  • Dimitri Papadopoulos

    (Commissariat à l’Energie Atomique et aux Energies Alternatives)

  • Hugh Garavan

    (Institute of Neuroscience, Trinity College Dublin
    University of Vermont)

  • Penny Gowland

    (School of Physics and Astronomy, University of Nottingham)

  • Andreas Heinz

    (Campus Charité Mitte, Charité—Universitätsmedizin Berlin)

  • Henrik Walter

    (Campus Charité Mitte, Charité—Universitätsmedizin Berlin)

  • Bernd Ittermann

    (Physikalisch-Technische Bundesanstalt (PTB))

  • Karl Mann

    (Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University)

  • Jean-Luc Martinot

    (Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 ‘Imaging & Psychiatry’, University Paris-Sud
    Maison de Solenn, APHP Ho^pital Cochin, University Paris Descartes)

  • Marie-Laure Paillère-Martinot

    (Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 ‘Imaging & Psychiatry’, University Paris-Sud
    Maison de Solenn, APHP Ho^pital Cochin, University Paris Descartes)

  • Frauke Nees

    (Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University)

  • Tomas Paus

    (McGill University and Genome Quebec Innovation Centre
    Rotman Research Institute, University of Toronto
    School of Psychology, University of Nottingham, Nottingham
    Montreal Neurological Institute, McGill University)

  • Zdenka Pausova

    (The Hospital for Sick Children, University of Toronto)

  • Luise Poustka

    (Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University)

  • Marcella Rietschel

    (Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University)

  • Trevor W. Robbins

    (Behavioural and Clinical Neurosciences Institute, University of Cambridge)

  • Michael N. Smolka

    (and Neuroimaging Center, Technische Universität Dresden)

  • Juergen Gallinat

    (Campus Charité Mitte, Charité—Universitätsmedizin Berlin)

  • Gunter Schumann

    (Institute of Psychiatry, King’s College London
    MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre)

  • Brian Knutson

    (Stanford University)

Abstract

Novelty-seeking tendencies in adolescents may promote innovation as well as problematic impulsive behaviour, including drug abuse. Previous research has not clarified whether neural hyper- or hypo-responsiveness to anticipated rewards promotes vulnerability in these individuals. Here we use a longitudinal design to track 144 novelty-seeking adolescents at age 14 and 16 to determine whether neural activity in response to anticipated rewards predicts problematic drug use. We find that diminished BOLD activity in mesolimbic (ventral striatal and midbrain) and prefrontal cortical (dorsolateral prefrontal cortex) regions during reward anticipation at age 14 predicts problematic drug use at age 16. Lower psychometric conscientiousness and steeper discounting of future rewards at age 14 also predicts problematic drug use at age 16, but the neural responses independently predict more variance than psychometric measures. Together, these findings suggest that diminished neural responses to anticipated rewards in novelty-seeking adolescents may increase vulnerability to future problematic drug use.

Suggested Citation

  • Christian Büchel & Jan Peters & Tobias Banaschewski & Arun L. W. Bokde & Uli Bromberg & Patricia J. Conrod & Herta Flor & Dimitri Papadopoulos & Hugh Garavan & Penny Gowland & Andreas Heinz & Henrik W, 2017. "Blunted ventral striatal responses to anticipated rewards foreshadow problematic drug use in novelty-seeking adolescents," Nature Communications, Nature, vol. 8(1), pages 1-11, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14140
    DOI: 10.1038/ncomms14140
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