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Fibronectin-guided migration of carcinoma collectives

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  • Sandeep Gopal

    (Université Côte d’Azur, CNRS, Inserm, Institut de Biologie Valrose (iBV)
    Present address: Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Australia)

  • Laurence Veracini

    (Université Côte d’Azur, CNRS, Inserm, Institut de Biologie Valrose (iBV))

  • Dominique Grall

    (Université Côte d’Azur, CNRS, Inserm, Institut de Biologie Valrose (iBV))

  • Catherine Butori

    (Université Côte d’Azur, Laboratoire de Pathologie Clinique et Expérimentale, Biobank [BB-0033-00025] CHU Nice-Pasteur)

  • Sébastien Schaub

    (Université Côte d’Azur, CNRS, Inserm, Institut de Biologie Valrose (iBV))

  • Stéphane Audebert

    (Aix Marseille Univ, CNRS, INSERM, Institut Paoli-Calmettes, CRCM, Marseille Protéomique)

  • Luc Camoin

    (Aix Marseille Univ, CNRS, INSERM, Institut Paoli-Calmettes, CRCM, Marseille Protéomique)

  • Emilie Baudelet

    (Aix Marseille Univ, CNRS, INSERM, Institut Paoli-Calmettes, CRCM, Marseille Protéomique)

  • Agata Radwanska

    (Université Côte d’Azur, CNRS, Inserm, Institut de Biologie Valrose (iBV))

  • Stéphanie Beghelli-de la Forest Divonne

    (Université Côte d’Azur, CNRS, Inserm, Institut de Biologie Valrose (iBV)
    Centre Antoine Lacassagne)

  • Shelia M. Violette

    (Biogen Inc.)

  • Paul H. Weinreb

    (Biogen Inc.)

  • Samah Rekima

    (Université Côte d’Azur, CNRS, Inserm, Institut de Biologie Valrose (iBV))

  • Marius Ilie

    (Université Côte d’Azur, Laboratoire de Pathologie Clinique et Expérimentale, Biobank [BB-0033-00025] CHU Nice-Pasteur)

  • Anne Sudaka

    (Université Côte d’Azur, CNRS, Inserm, Institut de Biologie Valrose (iBV)
    Centre Antoine Lacassagne)

  • Paul Hofman

    (Université Côte d’Azur, Laboratoire de Pathologie Clinique et Expérimentale, Biobank [BB-0033-00025] CHU Nice-Pasteur)

  • Ellen Van Obberghen-Schilling

    (Université Côte d’Azur, CNRS, Inserm, Institut de Biologie Valrose (iBV)
    Centre Antoine Lacassagne)

Abstract

Functional interplay between tumour cells and their neoplastic extracellular matrix plays a decisive role in malignant progression of carcinomas. Here we provide a comprehensive data set of the human HNSCC-associated fibroblast matrisome. Although much attention has been paid to the deposit of collagen, we identify oncofetal fibronectin (FN) as a major and obligate component of the matrix assembled by stromal fibroblasts from head and neck squamous cell carcinomas (HNSCC). FN overexpression in tumours from 435 patients corresponds to an independent unfavourable prognostic indicator. We show that migration of carcinoma collectives on fibrillar FN-rich matrices is achieved through αvβ6 and α9β1 engagement, rather than α5β1. Moreover, αvβ6-driven migration occurs independently of latent TGF-β activation and Smad-dependent signalling in tumour epithelial cells. These results provide insights into the adhesion-dependent events at the tumour–stroma interface that govern the collective mode of migration adopted by carcinoma cells to invade surrounding stroma in HNSCC.

Suggested Citation

  • Sandeep Gopal & Laurence Veracini & Dominique Grall & Catherine Butori & Sébastien Schaub & Stéphane Audebert & Luc Camoin & Emilie Baudelet & Agata Radwanska & Stéphanie Beghelli-de la Forest Divonne, 2017. "Fibronectin-guided migration of carcinoma collectives," Nature Communications, Nature, vol. 8(1), pages 1-15, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14105
    DOI: 10.1038/ncomms14105
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    Cited by:

    1. Jorge Barbazan & Carlos Pérez-González & Manuel Gómez-González & Mathieu Dedenon & Sophie Richon & Ernest Latorre & Marco Serra & Pascale Mariani & Stéphanie Descroix & Pierre Sens & Xavier Trepat & D, 2023. "Cancer-associated fibroblasts actively compress cancer cells and modulate mechanotransduction," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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