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Nonlinear detection of secondary isotopic chemical shifts in NMR through spin noise

Author

Listed:
  • Maria Theresia Pöschko

    (Institute of Organic Chemistry, Johannes Kepler University Linz)

  • Victor V. Rodin

    (Institute of Organic Chemistry, Johannes Kepler University Linz)

  • Judith Schlagnitweit

    (Institute of Organic Chemistry, Johannes Kepler University Linz
    Present address: Departement of Medical Biochemistry and Biophysics, Karolinska Institute, 171 77 Stockholm, Sweden)

  • Norbert Müller

    (Institute of Organic Chemistry, Johannes Kepler University Linz)

  • Hervé Desvaux

    (NIMBE, CEA, CNRS, Université Paris-Saclay, CEA/Saclay)

Abstract

The detection of minor species in the presence of large amounts of similar main components remains a key challenge in analytical chemistry, for instance, to obtain isotopic fingerprints. As an alternative to the classical NMR scheme based on coherent excitation and detection, here we introduce an approach based on spin-noise detection. Chemical shifts and transverse relaxation rates are determined using only the detection circuit. Thanks to a nonlinear effect in mixtures with small chemical shift dispersion, small signals on top of a larger one can be observed with increased sensitivity as bumps on a dip; the latter being the signature of the main magnetization. Experimental observations are underpinned by an analytical theory: the coupling between the magnetization and the coil provides an amplified detection capability of both small static magnetic field inhomogeneities and small NMR signals. This is illustrated by two-bond 12C/13C isotopic measurements.

Suggested Citation

  • Maria Theresia Pöschko & Victor V. Rodin & Judith Schlagnitweit & Norbert Müller & Hervé Desvaux, 2017. "Nonlinear detection of secondary isotopic chemical shifts in NMR through spin noise," Nature Communications, Nature, vol. 8(1), pages 1-9, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms13914
    DOI: 10.1038/ncomms13914
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    Cited by:

    1. Yunyi Wang & Aili Fan & Ryan D. Cohen & Guilherme Dal Poggetto & Zheng Huang & Haifeng Yang & Gary E. Martin & Edward C. Sherer & Mikhail Reibarkh & Xiao Wang, 2023. "Unequivocal identification of two-bond heteronuclear correlations in natural products at nanomole scale by i-HMBC," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

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