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Rare disruptive mutations in ciliary function genes contribute to testicular cancer susceptibility

Author

Listed:
  • Kevin Litchfield

    (The Institute of Cancer Research)

  • Max Levy

    (The Institute of Cancer Research)

  • Darshna Dudakia

    (The Institute of Cancer Research)

  • Paula Proszek

    (Centre for Molecular Pathology, The Royal Marsden NHS Foundation Trust)

  • Claire Shipley

    (Centre for Molecular Pathology, The Royal Marsden NHS Foundation Trust)

  • Sander Basten

    (Regenerative Medicine Center Utrecht, University Medical Center Utrecht)

  • Elizabeth Rapley

    (The Institute of Cancer Research)

  • D. Timothy Bishop

    (Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology)

  • Alison Reid
  • Robert Huddart
  • Peter Broderick

    (The Institute of Cancer Research)

  • David Gonzalez de Castro

    (Centre for Molecular Pathology, The Royal Marsden NHS Foundation Trust
    Centre for Cancer Research and Cell Biology, Queen's University Belfast)

  • Simon O'Connor

    (Centre for Molecular Pathology, The Royal Marsden NHS Foundation Trust)

  • Rachel H. Giles

    (Regenerative Medicine Center Utrecht, University Medical Center Utrecht)

  • Richard S. Houlston

    (The Institute of Cancer Research
    The Institute of Cancer Research)

  • Clare Turnbull

    (The Institute of Cancer Research
    William Harvey Research Institute, Queen Mary University
    Guy's and St Thomas' NHS Trust)

Abstract

Testicular germ cell tumour (TGCT) is the most common cancer in young men. Here we sought to identify risk factors for TGCT by performing whole-exome sequencing on 328 TGCT cases from 153 families, 634 sporadic TGCT cases and 1,644 controls. We search for genes that are recurrently affected by rare variants (minor allele frequency

Suggested Citation

  • Kevin Litchfield & Max Levy & Darshna Dudakia & Paula Proszek & Claire Shipley & Sander Basten & Elizabeth Rapley & D. Timothy Bishop & Alison Reid & Robert Huddart & Peter Broderick & David Gonzalez , 2016. "Rare disruptive mutations in ciliary function genes contribute to testicular cancer susceptibility," Nature Communications, Nature, vol. 7(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms13840
    DOI: 10.1038/ncomms13840
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