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Top-down modulation of olfactory-guided behaviours by the anterior olfactory nucleus pars medialis and ventral hippocampus

Author

Listed:
  • Afif J. Aqrabawi

    (University of Toronto)

  • Caleb J. Browne

    (University of Toronto)

  • Zahra Dargaei

    (University of Toronto)

  • Danielle Garand

    (University of Toronto)

  • C. Sahara Khademullah

    (University of Toronto)

  • Melanie A. Woodin

    (University of Toronto)

  • Jun Chul Kim

    (University of Toronto
    University of Toronto)

Abstract

Olfactory processing is thought to be actively modulated by the top-down input from cortical regions, but the behavioural function of these signals remains unclear. Here we find that cortical feedback from the anterior olfactory nucleus pars medialis (mAON) bidirectionally modulates olfactory sensitivity and olfaction-dependent behaviours. To identify a limbic input that tunes this mAON switch, we further demonstrate that optogenetic stimulation of ventral hippocampal inputs to the mAON is sufficient to alter olfaction-dependent behaviours.

Suggested Citation

  • Afif J. Aqrabawi & Caleb J. Browne & Zahra Dargaei & Danielle Garand & C. Sahara Khademullah & Melanie A. Woodin & Jun Chul Kim, 2016. "Top-down modulation of olfactory-guided behaviours by the anterior olfactory nucleus pars medialis and ventral hippocampus," Nature Communications, Nature, vol. 7(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms13721
    DOI: 10.1038/ncomms13721
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    Cited by:

    1. David Wolf & Renée Hartig & Yi Zhuo & Max F. Scheller & Mirko Articus & Marcel Moor & Valery Grinevich & Christiane Linster & Eleonora Russo & Wolfgang Weber-Fahr & Jonathan R. Reinwald & Wolfgang Kel, 2024. "Oxytocin induces the formation of distinctive cortical representations and cognitions biased toward familiar mice," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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