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Parvalbumin- and vasoactive intestinal polypeptide-expressing neocortical interneurons impose differential inhibition on Martinotti cells

Author

Listed:
  • F. Walker

    (University Medical Center Göttingen, Institute for Neuroanatomy)

  • M. Möck

    (University Medical Center Göttingen, Institute for Neuroanatomy)

  • M. Feyerabend

    (University Medical Center Göttingen, Institute for Neuroanatomy)

  • J. Guy

    (University Medical Center Göttingen, Institute for Neuroanatomy)

  • R. J. Wagener

    (University Medical Center Göttingen, Institute for Neuroanatomy
    Present address: Department of Basic Neurosciences, Faculty of Medicine, University of Geneva, CH-1211 GENEVE 4, Switzerland)

  • D. Schubert

    (Radboud University Medical Centre Nijmegen, Donders Institute for Brain, Cognition and Behaviour)

  • J. F. Staiger

    (University Medical Center Göttingen, Institute for Neuroanatomy)

  • M. Witte

    (University Medical Center Göttingen, Institute for Neuroanatomy)

Abstract

Disinhibition of cortical excitatory cell gate information flow through and between cortical columns. The major contribution of Martinotti cells (MC) is providing dendritic inhibition to excitatory neurons and therefore they are a main component of disinhibitory connections. Here we show by means of optogenetics that MC in layers II/III of the mouse primary somatosensory cortex are inhibited by both parvalbumin (PV)- and vasoactive intestinal polypeptide (VIP)-expressing cells. Paired recordings revealed stronger synaptic input onto MC from PV cells than from VIP cells. Moreover, PV cell input showed frequency-independent depression, whereas VIP cell input facilitated at high frequencies. These differences in the properties of the two unitary connections enable disinhibition with distinct temporal features.

Suggested Citation

  • F. Walker & M. Möck & M. Feyerabend & J. Guy & R. J. Wagener & D. Schubert & J. F. Staiger & M. Witte, 2016. "Parvalbumin- and vasoactive intestinal polypeptide-expressing neocortical interneurons impose differential inhibition on Martinotti cells," Nature Communications, Nature, vol. 7(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms13664
    DOI: 10.1038/ncomms13664
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