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Taotie neurons regulate appetite in Drosophila

Author

Listed:
  • Yin Peng Zhan

    (State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences
    University of the Chinese Academy of Sciences)

  • Li Liu

    (State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences
    University of the Chinese Academy of Sciences)

  • Yan Zhu

    (State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences
    University of the Chinese Academy of Sciences)

Abstract

The brain has an essential role in maintaining a balance between energy intake and expenditure of the body. Deciphering the processes underlying the decision-making for timely feeding of appropriate amounts may improve our understanding of physiological and psychological disorders related to feeding control. Here, we identify a group of appetite-enhancing neurons in a behavioural screen for flies with increased appetite. Manipulating the activity of these neurons, which we name Taotie neurons, induces bidirectional changes in feeding motivation. Long-term stimulation of Taotie neurons results in flies with highly obese phenotypes. Furthermore, we show that the in vivo activity of Taotie neurons in the neuroendocrine region reflects the hunger/satiety states of un-manipulated animals, and that appetitive-enhancing Taotie neurons control the secretion of insulin, a known regulator of feeding behaviour. Thus, our study reveals a new set of neurons regulating feeding behaviour in the high brain regions that represents physiological hunger states and control feeding behaviour in Drosophila.

Suggested Citation

  • Yin Peng Zhan & Li Liu & Yan Zhu, 2016. "Taotie neurons regulate appetite in Drosophila," Nature Communications, Nature, vol. 7(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms13633
    DOI: 10.1038/ncomms13633
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    Cited by:

    1. Maria E Yurgel & Priyanka Kakad & Meet Zandawala & Dick R Nässel & Tanja A Godenschwege & Alex C Keene, 2019. "A single pair of leucokinin neurons are modulated by feeding state and regulate sleep–metabolism interactions," PLOS Biology, Public Library of Science, vol. 17(2), pages 1-26, February.

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