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Tectal-derived interneurons contribute to phasic and tonic inhibition in the visual thalamus

Author

Listed:
  • Polona Jager

    (Institute of Psychiatry, Psychology and Neuroscience, King’s College London)

  • Zhiwen Ye

    (Imperial College London)

  • Xiao Yu

    (Imperial College London)

  • Laskaro Zagoraiou

    (Biomedical Research Foundation Academy of Athens)

  • Hong-Ting Prekop

    (Institute of Psychiatry, Psychology and Neuroscience, King’s College London)

  • Juha Partanen

    (University of Helsinki)

  • Thomas M. Jessell

    (Howard Hughes Medical Institute, Columbia University)

  • William Wisden

    (Imperial College London
    Centre for Neurotechnology, Imperial College London)

  • Stephen G. Brickley

    (Imperial College London
    Centre for Neurotechnology, Imperial College London)

  • Alessio Delogu

    (Institute of Psychiatry, Psychology and Neuroscience, King’s College London)

Abstract

The release of GABA from local interneurons in the dorsal lateral geniculate nucleus (dLGN-INs) provides inhibitory control during visual processing within the thalamus. It is commonly assumed that this important class of interneurons originates from within the thalamic complex, but we now show that during early postnatal development Sox14/Otx2-expressing precursor cells migrate from the dorsal midbrain to generate dLGN-INs. The unexpected extra-diencephalic origin of dLGN-INs sets them apart from GABAergic neurons of the reticular thalamic nucleus. Using optogenetics we show that at increased firing rates tectal-derived dLGN-INs generate a powerful form of tonic inhibition that regulates the gain of thalamic relay neurons through recruitment of extrasynaptic high-affinity GABAA receptors. Therefore, by revising the conventional view of thalamic interneuron ontogeny we demonstrate how a previously unappreciated mesencephalic population controls thalamic relay neuron excitability.

Suggested Citation

  • Polona Jager & Zhiwen Ye & Xiao Yu & Laskaro Zagoraiou & Hong-Ting Prekop & Juha Partanen & Thomas M. Jessell & William Wisden & Stephen G. Brickley & Alessio Delogu, 2016. "Tectal-derived interneurons contribute to phasic and tonic inhibition in the visual thalamus," Nature Communications, Nature, vol. 7(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms13579
    DOI: 10.1038/ncomms13579
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