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Integrin α7 is a functional cancer stem cell surface marker in oesophageal squamous cell carcinoma

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  • Xiao-Yan Ming

    (Li Ka Shing Faculty of Medicine, The University of Hong Kong
    Centre for Cancer Research, Li Ka Shing Faculty of Medicine, The University of Hong Kong)

  • Li Fu

    (Shenzhen Key Laboratory of Translational Medicine of Tumor and Cancer Research Centre, School of Medicine, Shenzhen University)

  • Li-Yi Zhang

    (Li Ka Shing Faculty of Medicine, The University of Hong Kong
    Centre for Cancer Research, Li Ka Shing Faculty of Medicine, The University of Hong Kong)

  • Yan-Ru Qin

    (The First Affiliated Hospital, Zhengzhou University)

  • Ting-Ting Cao

    (Li Ka Shing Faculty of Medicine, The University of Hong Kong
    Shenzhen Key Laboratory of Translational Medicine of Tumor and Cancer Research Centre, School of Medicine, Shenzhen University)

  • Kwok Wah Chan

    (Centre for Cancer Research, Li Ka Shing Faculty of Medicine, The University of Hong Kong
    Li Ka Shing Faculty of Medicine, The University of Hong Kong)

  • Stephanie Ma

    (Centre for Cancer Research, Li Ka Shing Faculty of Medicine, The University of Hong Kong
    School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong)

  • Dan Xie

    (State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University Cancer Center)

  • Xin-Yuan Guan

    (Li Ka Shing Faculty of Medicine, The University of Hong Kong
    Centre for Cancer Research, Li Ka Shing Faculty of Medicine, The University of Hong Kong
    State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University Cancer Center)

Abstract

Non-CG methylation has been associated with stemness regulation in embryonic stem cells. By comparing differentially expressed genes affected by non-CG methylation between tumour and corresponding non-tumour tissues in oesophageal squamous cell carcinoma (OSCC), we find that Integrin α7 (ITGA7) is characterized as a potential cancer stem cell (CSC) marker. Clinical data show that a high frequency of ITGA7+ cells in OSCC tissues is significantly associated with poor differentiation, lymph node metastasis and worse prognosis. Functional studies demonstrate that both sorted ITGA7+ cells and ITGA7 overexpressing cells display enhanced stemness features, including elevated expression of stemness-associated genes and epithelial–mesenchymal transition features, as well as increased abilities to self-renew, differentiate and resist chemotherapy. Mechanistic studies find that ITGA7 regulates CSC properties through the activation of the FAK-mediated signalling pathways. As knockdown of ITGA7 can effectively reduce the stemness of OSCC cells, ITGA7 could be a potential therapeutic target in OSCC treatment.

Suggested Citation

  • Xiao-Yan Ming & Li Fu & Li-Yi Zhang & Yan-Ru Qin & Ting-Ting Cao & Kwok Wah Chan & Stephanie Ma & Dan Xie & Xin-Yuan Guan, 2016. "Integrin α7 is a functional cancer stem cell surface marker in oesophageal squamous cell carcinoma," Nature Communications, Nature, vol. 7(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms13568
    DOI: 10.1038/ncomms13568
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