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Structural basis for Epstein–Barr virus host cell tropism mediated by gp42 and gHgL entry glycoproteins

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  • Karthik Sathiyamoorthy

    (Stanford University School of Medicine)

  • Yao Xiong Hu

    (Stanford University School of Medicine)

  • Britta S. Möhl

    (Feinberg School of Medicine, Northwestern University)

  • Jia Chen

    (Feinberg School of Medicine, Northwestern University)

  • Richard Longnecker

    (Feinberg School of Medicine, Northwestern University)

  • Theodore S. Jardetzky

    (Stanford University School of Medicine)

Abstract

Herpesvirus entry into host cells is mediated by multiple virally encoded receptor binding and membrane fusion glycoproteins. Despite their importance in host cell tropism and associated disease pathology, the underlying and essential interactions between these viral glycoproteins remain poorly understood. For Epstein–Barr virus (EBV), gHgL/gp42 complexes bind HLA class II to activate membrane fusion with B cells, but gp42 inhibits fusion and entry into epithelial cells. To clarify the mechanism by which gp42 controls the cell specificity of EBV infection, here we determined the structure of gHgL/gp42 complex bound to an anti-gHgL antibody (E1D1). The critical regulator of EBV tropism is the gp42 N-terminal domain, which tethers the HLA-binding domain to gHgL by wrapping around the exterior of three gH domains. Both the gp42 N-terminal domain and E1D1 selectively inhibit epithelial-cell fusion; however, they engage distinct surfaces of gHgL. These observations clarify key determinants of EBV host cell tropism.

Suggested Citation

  • Karthik Sathiyamoorthy & Yao Xiong Hu & Britta S. Möhl & Jia Chen & Richard Longnecker & Theodore S. Jardetzky, 2016. "Structural basis for Epstein–Barr virus host cell tropism mediated by gp42 and gHgL entry glycoproteins," Nature Communications, Nature, vol. 7(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms13557
    DOI: 10.1038/ncomms13557
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    Cited by:

    1. Qian-Ying Zhu & Sisi Shan & Jinfang Yu & Si-Ying Peng & Cong Sun & Yanan Zuo & Lan-Yi Zhong & Shu-Mei Yan & Xiao Zhang & Ziqing Yang & Yong-Jian Peng & Xuanling Shi & Su-Mei Cao & Xinquan Wang & Mu-Sh, 2021. "A potent and protective human neutralizing antibody targeting a novel vulnerable site of Epstein-Barr virus," Nature Communications, Nature, vol. 12(1), pages 1-13, December.

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