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Autophagy controls centrosome number by degrading Cep63

Author

Listed:
  • Yuichiro Watanabe

    (Medical Research Institute, Tokyo Medical and Dental University (TMDU)
    Tokyo Medical and Dental University)

  • Shinya Honda

    (Medical Research Institute, Tokyo Medical and Dental University (TMDU))

  • Akimitsu Konishi

    (Medical Research Institute, Tokyo Medical and Dental University (TMDU)
    Present address: Department of Biochemistry, Gunma University Graduate School of Medicine, 3-39-22 Showa, Maebashi, Gunma 371-8511, Japan)

  • Satoko Arakawa

    (Medical Research Institute, Tokyo Medical and Dental University (TMDU))

  • Michiko Murohashi

    (Medical Research Institute, Tokyo Medical and Dental University (TMDU))

  • Hirofumi Yamaguchi

    (Medical Research Institute, Tokyo Medical and Dental University (TMDU))

  • Satoru Torii

    (Medical Research Institute, Tokyo Medical and Dental University (TMDU))

  • Minoru Tanabe

    (Tokyo Medical and Dental University)

  • Shinji Tanaka

    (Graduate School of Medicine, Tokyo Medical and Dental University)

  • Eiji Warabi

    (Faculty of Medicine, University of Tsukuba)

  • Shigeomi Shimizu

    (Medical Research Institute, Tokyo Medical and Dental University (TMDU))

Abstract

Centrosome number is associated with the chromosome segregation and genomic stability. The ubiquitin–proteasome system is considered to be the main regulator of centrosome number. However, here we show that autophagy also regulates the number of centrosomes. Autophagy-deficient cells carry extra centrosomes. The autophagic regulation of centrosome number is dependent on a centrosomal protein of 63 (Cep63) given that cells lacking autophagy contain multiple Cep63 dots that are engulfed and digested by autophagy in wild-type cells, and that the upregulation of Cep63 increases centrosome number. Cep63 is recruited to autophagosomes via interaction with p62, a molecule crucial for selective autophagy. In vivo, hematopoietic cells from autophagy-deficient and p62−/− mice also contained multiple centrosomes. These results indicate that autophagy controls centrosome number by degrading Cep63.

Suggested Citation

  • Yuichiro Watanabe & Shinya Honda & Akimitsu Konishi & Satoko Arakawa & Michiko Murohashi & Hirofumi Yamaguchi & Satoru Torii & Minoru Tanabe & Shinji Tanaka & Eiji Warabi & Shigeomi Shimizu, 2016. "Autophagy controls centrosome number by degrading Cep63," Nature Communications, Nature, vol. 7(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms13508
    DOI: 10.1038/ncomms13508
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    Cited by:

    1. Yaping Huang & Changzheng Lu & Hanzhi Wang & Liya Gu & Yang-Xin Fu & Guo-Min Li, 2023. "DNAJA2 deficiency activates cGAS-STING pathway via the induction of aberrant mitosis and chromosome instability," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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