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The Hippo signalling pathway coordinates organ growth and limits developmental variability by controlling dilp8 expression

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  • Emilie Boone

    (University Nice Sophia Antipolis, CNRS, Inserm, iBV)

  • Julien Colombani

    (University Nice Sophia Antipolis, CNRS, Inserm, iBV)

  • Ditte S. Andersen

    (University Nice Sophia Antipolis, CNRS, Inserm, iBV)

  • Pierre Léopold

    (University Nice Sophia Antipolis, CNRS, Inserm, iBV)

Abstract

Coordination of organ growth during development is required to generate fit individuals with fixed proportions. We recently identified Drosophila Dilp8 as a key hormone in coupling organ growth with animal maturation. In addition, dilp8 mutant flies exhibit elevated fluctuating asymmetry (FA) demonstrating a function for Dilp8 in ensuring developmental stability. The signals regulating Dilp8 activity during normal development are not yet known. Here, we show that the transcriptional co-activators of the Hippo (Hpo) pathway, Yorkie (Yki, YAP/TAZ) and its DNA-binding partner Scalloped (Sd), directly regulate dilp8 expression through a Hpo-responsive element (HRE) in the dilp8 promoter. We further demonstrate that mutation of the HRE by genome-editing results in animals with increased FA, thereby mimicking full dilp8 loss of function. Therefore, our results indicate that growth coordination of organs is connected to their growth status through a feedback loop involving Hpo and Dilp8 signalling pathways.

Suggested Citation

  • Emilie Boone & Julien Colombani & Ditte S. Andersen & Pierre Léopold, 2016. "The Hippo signalling pathway coordinates organ growth and limits developmental variability by controlling dilp8 expression," Nature Communications, Nature, vol. 7(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms13505
    DOI: 10.1038/ncomms13505
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    Cited by:

    1. D. Blanco-Obregon & K. El Marzkioui & F. Brutscher & V. Kapoor & L. Valzania & D. S. Andersen & J. Colombani & S. Narasimha & D. McCusker & P. Léopold & L. Boulan, 2022. "A Dilp8-dependent time window ensures tissue size adjustment in Drosophila," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    2. Klement Stojanovski & Ioana Gheorghe & Peter Lenart & Anne Lanjuin & William B. Mair & Benjamin D. Towbin, 2023. "Maintenance of appropriate size scaling of the C. elegans pharynx by YAP-1," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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