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A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape

Author

Listed:
  • Janina S. Ried

    (Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health)

  • Janina Jeff M.

    (The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai)

  • Audrey Y. Chu

    (Brigham and Women's Hospital)

  • Jennifer L. Bragg-Gresham

    (Kidney Epidemiology and Cost Center, Internal Medicine-Nephrology, University of Michigan)

  • Jenny van Dongen

    (VU University)

  • Jennifer E. Huffman

    (MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh)

  • Tarunveer S. Ahluwalia

    (Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen
    Steno Diabetes Center A/S
    COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen)

  • Gemma Cadby

    (Centre for Genetic Origins of Health and Disease, University of Western Australia)

  • Niina Eklund

    (National Institute for Health and Welfare (THL))

  • Joel Eriksson

    (Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg)

  • Tõnu Esko

    (Broad Institute of the Massachusetts Institute of Technology and Harvard University
    Boston Children's Hospital
    Estonian Genome Center, University of Tartu
    Harvard Medical School)

  • Mary F. Feitosa

    (Washington University School of Medicine)

  • Anuj Goel

    (University of Oxford
    Wellcome Trust Centre for Human Genetics, University of Oxford)

  • Mathias Gorski

    (University Hospital Regensburg
    Institute of Epidemiology and Preventive Medicine, University of Regensburg)

  • Caroline Hayward

    (MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh)

  • Nancy L. Heard-Costa

    (National Heart, Lung, and Blood Institute, the Framingham Heart Study
    Boston University School of Medicine)

  • Anne U. Jackson

    (Center for Statistical Genetics, University of Michigan)

  • Eero Jokinen

    (Hospital for Children and Adolescents, University of Helsinki)

  • Stavroula Kanoni

    (Wellcome Trust Sanger Institute, Human Genetics
    William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London)

  • Kati Kristiansson

    (National Institute for Health and Welfare (THL)
    Institute for Molecular Medicine Finland, University of Helsinki)

  • Zoltán Kutalik

    (Swiss Institute of Bioinformatics
    University of Lausanne
    Institute of Social and Preventive Medicine, University Hospital Lausanne (CHUV))

  • Jari Lahti

    (Folkhälsan Research Centre
    Institute of Behavioural Sciences, University of Helsinki)

  • Jian'an Luan

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus)

  • Reedik Mägi

    (Estonian Genome Center, University of Tartu
    Wellcome Trust Centre for Human Genetics, University of Oxford)

  • Anubha Mahajan

    (Wellcome Trust Centre for Human Genetics, University of Oxford)

  • Massimo Mangino

    (King's College London)

  • Carolina Medina-Gomez

    (Erasmus Medical Center
    Erasmus Medical Center)

  • Keri L. Monda

    (University of North Carolina at Chapel Hill
    The Center for Observational Research, Amgen Inc.)

  • Ilja M. Nolte

    (University of Groningen, University Medical Center Groningen)

  • Louis Pérusse

    (Laval University
    Institute of Nutrition and Functional Foods, Laval University)

  • Inga Prokopenko

    (Wellcome Trust Centre for Human Genetics, University of Oxford
    School of Public Health, Imperial College London
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital)

  • Lu Qi

    (Brigham and Women’s Hospital and Harvard Medical School
    Harvard School of Public Health)

  • Lynda M. Rose

    (Brigham and Women's Hospital)

  • Erika Salvi

    (University of Milano at San Paolo Hospital
    Filarete Foundation, Genomic and Bioinformatics Unit)

  • Megan T. Smith

    (University of Washington)

  • Harold Snieder

    (University of Groningen, University Medical Center Groningen)

  • Alena Stančáková

    (University of Eastern Finland and Kuopio University Hospital)

  • Yun Ju Sung

    (Washington University School of Medicine)

  • Ioanna Tachmazidou

    (Wellcome Trust Sanger Institute, Human Genetics)

  • Alexander Teumer

    (Institute for Community Medicine, University Medicine Greifswald
    Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald)

  • Gudmar Thorleifsson

    (deCODE Genetics, Amgen inc.)

  • Pim van der Harst

    (Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands-Netherlands Heart Institute
    University of Groningen, University Medical Center Groningen
    University of Groningen, University Medical Center Groningen)

  • Ryan W. Walker

    (The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai
    The Icahn School of Medicine at Mount Sinai)

  • Sophie R. Wang

    (Harvard Medical School
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology
    Boston Children's Hospital
    Boston's Children's Hospital)

  • Sarah H. Wild

    (Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh)

  • Sara M. Willems

    (Genetic Epidemiology Unit, Erasmus University Medical Center)

  • Andrew Wong

    (MRC Unit for Lifelong Health & Ageing at UCL)

  • Weihua Zhang

    (Imperial College London
    Ealing Hospital NHS Trust)

  • Eva Albrecht

    (Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health)

  • Alexessander Couto Alves

    (MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College)

  • Stephan J. L. Bakker

    (University of Groningen, University Medical Center Groningen)

  • Cristina Barlassina

    (University of Milano at San Paolo Hospital
    Filarete Foundation, Genomic and Bioinformatics Unit)

  • Traci M. Bartz

    (University of Washington
    University of Washington
    Cardiovascular Health Research Unit, University of Washington)

  • John Beilby

    (Pathwest Laboratory Medicine of Western Australia
    School of Pathology and Laboratory Medicine, University of Western Australia)

  • Claire Bellis

    (Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology
    Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research of Singapore)

  • Richard N. Bergman

    (Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center)

  • Sven Bergmann

    (Swiss Institute of Bioinformatics
    University of Lausanne)

  • John Blangero

    (South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley)

  • Matthias Blüher

    (University of Leipzig, IFB Adiposity Diseases
    University of Leipzig)

  • Eric Boerwinkle

    (Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center)

  • Lori L. Bonnycastle

    (Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH)

  • Stefan R. Bornstein

    (Medical Faculty Carl Gustav Carus, University of Dresden)

  • Marcel Bruinenberg

    (University of Groningen, University Medical Center Groningen, The LifeLines Cohort Study)

  • Harry Campbell

    (Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh)

  • Yii-Der Ida Chen

    (Los Angeles BioMedical Resesarch Institute at Harbor-UCLA Medical Center)

  • Charleston W. K. Chiang

    (University of California)

  • Peter S. Chines

    (Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH)

  • Francis S Collins

    (Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH)

  • Fracensco Cucca

    (University of Sassari)

  • L Adrienne Cupples

    (National Heart, Lung, and Blood Institute, the Framingham Heart Study)

  • Francesca D’Avila

    (University of Milano at San Paolo Hospital
    Filarete Foundation, Genomic and Bioinformatics Unit)

  • Eco J .C. de Geus

    (VU University
    EMGO Institute for Health and Care Research, VU University Medical Center)

  • George Dedoussis

    (School of Health Science and Education, Harokopio University)

  • Maria Dimitriou

    (Wellcome Trust Sanger Institute, Human Genetics
    School of Health Science and Education, Harokopio University)

  • Angela Döring

    (Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health
    Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health)

  • Johan G. Eriksson

    (Folkhälsan Research Centre
    National Institute for Health and Welfare
    University of Helsinki)

  • Aliki-Eleni Farmaki

    (School of Health Science and Education, Harokopio University)

  • Martin Farrall

    (University of Oxford
    Wellcome Trust Centre for Human Genetics, University of Oxford)

  • Teresa Ferreira

    (Wellcome Trust Centre for Human Genetics, University of Oxford)

  • Krista Fischer

    (Estonian Genome Center, University of Tartu)

  • Nita G. Forouhi

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus)

  • Nele Friedrich

    (Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald)

  • Anette Prior Gjesing

    (Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen)

  • Nicola Glorioso

    (Hypertension and Related Disease Centre, AOU-University of Sassari)

  • Mariaelisa Graff

    (University of North Carolina at Chapel Hill)

  • Harald Grallert

    (Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health
    German Center for Diabetes Research (DZD)
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health)

  • Niels Grarup

    (Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen)

  • Jürgen Gräßler

    (Pathobiochemistry, Technische Universitaet)

  • Jagvir Grewal

    (Imperial College London
    Ealing Hospital NHS Trust)

  • Anders Hamsten

    (Karolinska Institutet
    Atherosclerosis Research Unit, Karolinska Institutet
    Center for Molecular Medicine, Karolinska University Hospital)

  • Marie Neergaard Harder

    (Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen)

  • Catharina A. Hartman

    (University of Groningen, University Medical Center Groningen, Interdisciplinary Center Psychopathology and Emotion Regulation)

  • Maija Hassinen

    (Kuopio Research Institute of Exercise Medicine)

  • Nicholas Hastie

    (MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh)

  • Andrew Tym Hattersley

    (Institue of Biomedical & Clinical Science, University of Exeter, Barrack Road, Exeter EX2 5DW, UK)

  • Aki S. Havulinna

    (National Institute for Health and Welfare (THL))

  • Markku Heliövaara

    (National Institute for Health and Welfare (THL))

  • Hans Hillege

    (University of Groningen, University Medical Center Groningen)

  • Albert Hofman

    (Erasmus Medical Center)

  • Oddgeir Holmen

    (Norwegian University of Science and Technology)

  • Georg Homuth

    (Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald)

  • Jouke-Jan Hottenga

    (VU University)

  • Jennie Hui

    (Pathwest Laboratory Medicine of Western Australia
    School of Pathology and Laboratory Medicine, University of Western Australia
    School of Population Health, University of Western Australia)

  • Lise Lotte Husemoen

    (Research Centre for Prevention and Health, Glostrup Hospital)

  • Pirro G. Hysi

    (King's College London)

  • Aaron Isaacs

    (Genetic Epidemiology Unit, Erasmus University Medical Center)

  • Till Ittermann

    (Institute for Community Medicine, University Medicine Greifswald)

  • Shapour Jalilzadeh

    (University of Oxford
    Wellcome Trust Centre for Human Genetics, University of Oxford)

  • Alan L. James

    (Sir Charles Gairdner Hospital)

  • Torben Jørgensen

    (Faculty of Health and Medical Sciences, University of Copenhagen
    Faculty of Medicine, University of Aalborg
    Research Centre for Prevention and Health, Capital Region of Denmark)

  • Pekka Jousilahti

    (National Institute for Health and Welfare (THL))

  • Antti Jula

    (National Institute for Health and Welfare (THL))

  • Johanne Marie Justesen

    (Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen)

  • Anne E. Justice

    (University of North Carolina at Chapel Hill)

  • Mika Kähönen

    (Tampere University Hospital
    University of Tampere School of Medicine)

  • Maria Karaleftheri

    (Echinos Medical Centre)

  • Kay Tee Khaw

    (Clinical Gerontology Unit, Box 251, Addenbrooke's Hospital, Hills Road)

  • Sirkka M. Keinanen-Kiukaanniemi

    (Faculty of Medicine, Institute of Health Sciences, University of Oulu
    Unit of General Practice, Oulu University Hospital)

  • Leena Kinnunen

    (National Institute for Health and Welfare)

  • Paul B. Knekt

    (National Institute for Health and Welfare (THL))

  • Heikki A. Koistinen

    (National Institute for Health and Welfare
    University of Helsinki and Helsinki University Central Hospital
    Minerva Foundation Institute for Medical Research)

  • Ivana Kolcic

    (Faculty of Medicine, University of Split)

  • Ishminder K. Kooner

    (Ealing Hospital NHS Trust)

  • Seppo Koskinen

    (National Institute for Health and Welfare (THL))

  • Peter Kovacs

    (University of Leipzig, IFB Adiposity Diseases)

  • Theodosios Kyriakou

    (University of Oxford
    Wellcome Trust Centre for Human Genetics, University of Oxford)

  • Tomi Laitinen

    (Kuopio University Hospital
    University of Eastern Finland)

  • Claudia Langenberg

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus
    UCL)

  • Alexandra M. Lewin

    (MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College)

  • Peter Lichtner

    (Institute of Human Genetics, Helmholtz Zentrum München-German Research Center for Environmental Health)

  • Cecilia M. Lindgren

    (Broad Institute of the Massachusetts Institute of Technology and Harvard University
    Wellcome Trust Centre for Human Genetics, University of Oxford
    The Big Data Institute, University of Oxford)

  • Jaana Lindström

    (National Institute for Health and Welfare (THL))

  • Allan Linneberg

    (Research Centre for Prevention and Health, Glostrup Hospital
    Faculty of Health and Medical Sciences, University of Copenhagen
    Rigshospitalet)

  • Roberto Lorbeer

    (Institute for Community Medicine, University Medicine Greifswald)

  • Mattias Lorentzon

    (Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg)

  • Robert Luben

    (Strangeways Research Laboratory Wort's Causeway)

  • Valeriya Lyssenko

    (Steno Diabetes Center A/S
    Diabetes & Endocrinology Unit, Lund University)

  • Satu Männistö

    (National Institute for Health and Welfare (THL))

  • Paolo Manunta

    (Chair of Nephrology, Università Vita Salute San Raffaele and Genomics of Renal Diseases and Hypertension Unit, IRCCS San Raffaele Scientific Institute)

  • Irene Mateo Leach

    (University of Groningen, University Medical Center Groningen)

  • Wendy L. McArdle

    (School of Social and Community Medicine, University of Bristol)

  • Barbara Mcknight

    (University of Washington
    Cardiovascular Health Research Unit, University of Washington
    Divison of Public Health Sciences, Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center)

  • Karen L. Mohlke

    (University of North Carolina)

  • Evelin Mihailov

    (Estonian Genome Center, University of Tartu)

  • Lili Milani

    (Estonian Genome Center, University of Tartu)

  • Rebecca Mills

    (Ealing Hospital NHS Trust)

  • May E. Montasser

    (Diabetes & Nutrition, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine)

  • Andrew P. Morris

    (Wellcome Trust Centre for Human Genetics, University of Oxford
    University of Liverpool)

  • Gabriele Müller

    (Center for Evidence Based Healthcare, University of Dresden, Medical Faculty Carl Gustav Carus)

  • Arthur W. Musk

    (Sir Charles Gairdner Hospital)

  • Narisu Narisu

    (Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH)

  • Ken K. Ong

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus
    MRC Unit for Lifelong Health & Ageing at UCL
    University of Cambridge)

  • Ben A. Oostra

    (Genetic Epidemiology Unit, Erasmus University Medical Center)

  • Clive Osmond

    (MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital)

  • Aarno Palotie

    (Institute for Molecular Medicine Finland, University of Helsinki
    Massachusetts General Hospital, Center for Human Genetic Research, Psychiatric and Neurodevelopmental Genetics Unit)

  • James S. Pankow

    (School of Public Health, University of Minnesota)

  • Lavinia Paternoster

    (MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol)

  • Brenda W. Penninx

    (VU University Medical Center)

  • Irene Pichler

    (Center for Biomedicine, European Academy Bozen/Bolzano (EURAC)
    Affiliated Institute of the University of Lübeck)

  • Maria G. Pilia

    (Istituto di Ricerca Genetica e Biomedica, CNR)

  • Ozren Polašek

    (Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh
    Faculty of Medicine, University of Split)

  • Peter P. Pramstaller

    (Center for Biomedicine, European Academy Bozen/Bolzano (EURAC)
    Affiliated Institute of the University of Lübeck
    University of Lübeck
    General Central Hospital)

  • Olli T Raitakari

    (Turku University Hospital
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku)

  • Tuomo Rankinen

    (Human Genomics Laboratory, Pennington Biomedical Research Center)

  • D. C. Rao

    (Washington University School of Medicine
    Washington University School of Medicine)

  • Nigel W. Rayner

    (Wellcome Trust Centre for Human Genetics, University of Oxford
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital
    Wellcome Trust Sanger Institute, Human Genetics)

  • Rasmus Ribel-Madsen

    (Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen)

  • Treva K. Rice

    (Washington University School of Medicine
    Washington University School of Medicine)

  • Marcus Richards

    (Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital
    MRC Unit for Lifelong Health & Ageing at UCL)

  • Paul M. Ridker

    (Brigham and Women's Hospital
    Harvard Medical School)

  • Fernando Rivadeneira

    (Erasmus Medical Center
    Erasmus Medical Center)

  • Kathy A. Ryan

    (Diabetes & Nutrition, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine)

  • Serena Sanna

    (Istituto di Ricerca Genetica e Biomedica, CNR)

  • Mark A. Sarzynski

    (Human Genomics Laboratory, Pennington Biomedical Research Center)

  • Salome Scholtens

    (University of Groningen, University Medical Center Groningen)

  • Robert A. Scott

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus)

  • Sylvain Sebert

    (School of Public Health, Imperial College London
    Biocenter Oulu, University of Oulu
    Center For Life-Course Health Research, University of Oulu)

  • Lorraine Southam

    (Wellcome Trust Centre for Human Genetics, University of Oxford
    Wellcome Trust Sanger Institute, Human Genetics)

  • Thomas Hempel Sparsø

    (Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen)

  • Valgerdur Steinthorsdottir

    (deCODE Genetics, Amgen inc.)

  • Kathleen Stirrups

    (Wellcome Trust Sanger Institute, Human Genetics
    William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London)

  • Ronald P. Stolk

    (University of Groningen, University Medical Center Groningen)

  • Konstantin Strauch

    (Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health
    Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität)

  • Heather M. Stringham

    (Center for Statistical Genetics, University of Michigan)

  • Morris A. Swertz

    (University of Groningen, University Medical Center Groningen)

  • Amy J. Swift

    (Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH)

  • Anke Tönjes

    (University of Leipzig)

  • Emmanouil Tsafantakis

    (Anogia Medical Centre)

  • Peter J. van der Most

    (University of Groningen, University Medical Center Groningen)

  • Jana V. Van Vliet-Ostaptchouk

    (University of Groningen, University Medical Center Groningen)

  • Liesbeth Vandenput

    (Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg)

  • Erkki Vartiainen

    (National Institute for Health and Welfare (THL))

  • Cristina Venturini

    (King's College London
    Institute of Ophthalmology, University College London)

  • Niek Verweij

    (University of Groningen, University Medical Center Groningen)

  • Jorma S. Viikari

    (University of Turku
    Turku University Hospital)

  • Veronique Vitart

    (MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh)

  • Marie-Claude Vohl

    (Institute of Nutrition and Functional Foods, Laval University
    School of Nutrition, Laval University)

  • Judith M. Vonk

    (University of Groningen, University Medical Center Groningen)

  • Gérard Waeber

    (University Hospital Lausanne (CHUV) and University of Lausanne)

  • Elisabeth Widén

    (Institute for Molecular Medicine Finland, University of Helsinki)

  • Gonneke Willemsen

    (VU University)

  • Tom Wilsgaard

    (Faculty of Health Sciences, University of Tromsø)

  • Thomas W. Winkler

    (Institute of Epidemiology and Preventive Medicine, University of Regensburg)

  • Alan F. Wright

    (MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh)

  • Laura M. Yerges-Armstrong

    (Diabetes & Nutrition, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine)

  • Jing Hua Zhao

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus)

  • M. Carola Zillikens

    (Erasmus Medical Center)

  • Dorret I. Boomsma

    (VU University)

  • Claude Bouchard

    (Human Genomics Laboratory, Pennington Biomedical Research Center)

  • John C. Chambers

    (Imperial College London
    Ealing Hospital NHS Trust
    Imperial College Healthcare NHS Trust)

  • Daniel I. Chasman

    (Brigham and Women's Hospital
    Harvard Medical School)

  • Daniele Cusi

    (University of Milano at San Paolo Hospital
    Filarete Foundation, Genomic and Bioinformatics Unit)

  • Ron T. Gansevoort

    (University of Groningen, University Medical Center Groningen)

  • Christian Gieger

    (Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health
    Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health)

  • Torben Hansen

    (Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen
    Faculty of Health Sciences, University of Southern Denmark)

  • Andrew A. Hicks

    (Center for Biomedicine, European Academy Bozen/Bolzano (EURAC)
    Affiliated Institute of the University of Lübeck)

  • Frank Hu

    (Brigham and Women’s Hospital and Harvard Medical School
    Harvard School of Public Health)

  • Kristian Hveem

    (Norwegian University of Science and Technology)

  • Marjo-Riitta Jarvelin

    (Biocenter Oulu, University of Oulu
    Unit of Primary Care, Oulu University Hospital
    MRC–PHE Centre for Environment & Health, School of Public Health, Imperial College
    Faculty of Medicine, Center for Life Course Epidemiology, University of Oulu)

  • Eero Kajantie

    (National Institute for Health and Welfare (THL)
    National Institute for Health and Welfare
    Children's Hospital, Helsinki University Hospital and University of Helsinki
    MRC Oulu, Oulu University Hospital and University of Oulu)

  • Jaspal S. Kooner

    (Ealing Hospital NHS Trust
    Imperial College Healthcare NHS Trust
    National Heart and Lung Institute, Imperial College London)

  • Diana Kuh

    (MRC Unit for Lifelong Health & Ageing at UCL)

  • Johanna Kuusisto

    (University of Eastern Finland and Kuopio University Hospital)

  • Markku Laakso

    (University of Eastern Finland and Kuopio University Hospital)

  • Timo A. Lakka

    (Kuopio Research Institute of Exercise Medicine
    Institute of Biomedicine, University of Eastern Finland, Kuopio Campus)

  • Terho Lehtimäki

    (University of Tampere School of Medicine
    Fimlab Laboratories and School of Medicine, University of Tampere)

  • Andres Metspalu

    (Estonian Genome Center, University of Tartu)

  • Inger Njølstad

    (Faculty of Health Sciences, University of Tromsø
    Faculty of Health Sciences, University of Tromsø)

  • Claes Ohlsson

    (Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg)

  • Albertine J. Oldehinkel

    (University of Groningen, University Medical Center Groningen, Interdisciplinary Center Psychopathology and Emotion Regulation)

  • Lyle J. Palmer

    (School of Public Health, University of Adelaide
    Robinson Research Institute, University of Adelaide)

  • Oluf Pedersen

    (Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen)

  • Markus Perola

    (National Institute for Health and Welfare (THL)
    Estonian Genome Center, University of Tartu
    Institute for Molecular Medicine Finland, University of Helsinki)

  • Annette Peters

    (Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health
    DZHK (German Centre for Cardiovascular Research), partnersite Munich Heart Alliance)

  • Bruce M. Psaty

    (Cardiovascular Health Research Unit, University of Washington
    University of Washington
    University of Washington
    Group Health Research Institute, Group Health Cooperative)

  • Hannu Puolijoki

    (South Ostrobothnia Central Hospital)

  • Rainer Rauramaa

    (Kuopio Research Institute of Exercise Medicine
    Kuopio University Hospital)

  • Igor Rudan

    (Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh)

  • Veikko Salomaa

    (National Institute for Health and Welfare (THL))

  • Peter E. H. Schwarz

    (Medical Faculty Carl Gustav Carus, University of Dresden
    Paul Langerhans Institute Dresden, German Center for Diabetes Research (DZD))

  • Alan R. Shudiner

    (Diabetes & Nutrition, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine
    Geriatric Research and Education Clinical Center, Vetrans Administration Medical Center)

  • Jan H. Smit

    (VU University Medical Center)

  • Thorkild I. A. Sørensen

    (Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen
    MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol
    Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospital, The Capital Region)

  • Timothy D. Spector

    (King's College London)

  • Kari Stefansson

    (deCODE Genetics, Amgen inc.
    Faculty of Medicine, University of Iceland)

  • Michael Stumvoll

    (University of Leipzig, IFB Adiposity Diseases
    University of Leipzig)

  • Angelo Tremblay

    (Laval University)

  • Jaakko Tuomilehto

    (Diabetes Prevention Unit, National Institute for Health and Welfare
    Centre for Vascular Prevention, Danube-University Krems
    Diabetes Research Group, King Abdulaziz University)

  • André G. Uitterlinden

    (Erasmus Medical Center
    Erasmus Medical Center)

  • Matti Uusitupa

    (University of Eastern Finland
    Research Unit, Kuopio University Hospital)

  • Uwe Völker

    (Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald
    DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald)

  • Peter Vollenweider

    (University Hospital Lausanne (CHUV) and University of Lausanne)

  • Nicholas J. Wareham

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus)

  • Hugh Watkins

    (University of Oxford
    Wellcome Trust Centre for Human Genetics, University of Oxford)

  • James F. Wilson

    (MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
    Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh)

  • Eleftheria Zeggini

    (Wellcome Trust Sanger Institute, Human Genetics)

  • Goncalo R. Abecasis

    (Center for Statistical Genetics, University of Michigan)

  • Michael Boehnke

    (Center for Statistical Genetics, University of Michigan)

  • Ingrid B. Borecki

    (Washington University School of Medicine)

  • Panos Deloukas

    (William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
    Wellcome Trust Sanger Institute, Human Genetics
    Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University)

  • Cornelia M. van Duijn

    (Genetic Epidemiology Unit, Erasmus University Medical Center
    Center for Medical Systems Biology)

  • Caroline Fox

    (National Heart, Lung, and Blood Institute, the Framingham Heart Study
    Harvard Medical School)

  • Leif C. Groop

    (Diabetes & Endocrinology Unit, Lund University
    Finnish Institute for Molecular Medicine (FIMM), Helsinki University)

  • Iris M. Heid

    (Institute of Epidemiology and Preventive Medicine, University of Regensburg
    Institute of Genetic Epidemiology, Helmholtz Zentrum München)

  • David J. Hunter

    (Broad Institute of the Massachusetts Institute of Technology and Harvard University
    Brigham and Women’s Hospital and Harvard Medical School
    Harvard School of Public Health
    Harvard School of Public Health)

  • Robert C. Kaplan

    (Albert Einstein College of Medicine)

  • Mark I. McCarthy

    (Wellcome Trust Centre for Human Genetics, University of Oxford
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital
    Oxford NIHR Biomedical Research Centre)

  • Kari E. North

    (Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill)

  • Jeffrey R. O'Connell

    (Diabetes & Nutrition, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine)

  • David Schlessinger

    (National Institute on Aging, National Institutes of Health)

  • Unnur Thorsteinsdottir

    (deCODE Genetics, Amgen inc.
    Faculty of Medicine, University of Iceland)

  • David P. Strachan

    (Population Health Research Institute, St George's, University of London)

  • Timothy Frayling

    (Genetics of Complex Traits, University of Exeter Medical School, University of Exeter)

  • Joel N. Hirschhorn

    (Broad Institute of the Massachusetts Institute of Technology and Harvard University
    Boston Children's Hospital
    Harvard Medical School
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology)

  • Martina Müller-Nurasyid

    (Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health
    Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität
    DZHK (German Centre for Cardiovascular Research), partnersite Munich Heart Alliance
    University Hospital Grosshadern, Ludwig-Maximilians-Universität)

  • Ruth J. F. Loos

    (The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai
    MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus
    The Icahn School of Medicine at Mount Sinai
    The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai)

Abstract

Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a combination of anthropometric traits. We developed an approach that calculates averaged PCs (AvPCs) representing body shape derived from six anthropometric traits (body mass index, height, weight, waist and hip circumference, waist-to-hip ratio). The first four AvPCs explain >99% of the variability, are heritable, and associate with cardiometabolic outcomes. We performed genome-wide association analyses for each body shape composite phenotype across 65 studies and meta-analysed summary statistics. We identify six novel loci: LEMD2 and CD47 for AvPC1, RPS6KA5/C14orf159 and GANAB for AvPC3, and ARL15 and ANP32 for AvPC4. Our findings highlight the value of using multiple traits to define complex phenotypes for discovery, which are not captured by single-trait analyses, and may shed light onto new pathways.

Suggested Citation

  • Janina S. Ried & Janina Jeff M. & Audrey Y. Chu & Jennifer L. Bragg-Gresham & Jenny van Dongen & Jennifer E. Huffman & Tarunveer S. Ahluwalia & Gemma Cadby & Niina Eklund & Joel Eriksson & Tõnu Esko &, 2016. "A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape," Nature Communications, Nature, vol. 7(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms13357
    DOI: 10.1038/ncomms13357
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    Cited by:

    1. Saaket Agrawal & Minxian Wang & Marcus D. R. Klarqvist & Kirk Smith & Joseph Shin & Hesam Dashti & Nathaniel Diamant & Seung Hoan Choi & Sean J. Jurgens & Patrick T. Ellinor & Anthony Philippakis & Me, 2022. "Inherited basis of visceral, abdominal subcutaneous and gluteofemoral fat depots," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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